Soy isoflavones exert modest hormonal effects in premenopausal women
Soy isoflavones exert modest hormonal effects in premenopausal women
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DOI：
10.1210/jc.84.1.192
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发表时间：
1999-01-01
影响因子：
5.8
通讯作者：
Kurzer, MS
中科院分区：
文献类型：
--
作者：
Duncan, AM;Merz, BE;Kurzer, MS
大豆异黄酮被假设为负责与降低乳腺癌风险相关的激素作用的变化。为了验证这一假设，我们研究了14名绝经前妇女的饮食影响。异黄酮以大豆蛋白粉的形式摄入，并在三个月经周期加9天的随机交叉设计中相对于体重（对照饮食，10 +/- 1.1;低维生素D饮食，64 +/- 9.2;高维生素D饮食，128 +/- 16 mg/天）提供。在每个饮食期的最后6周期间，每隔一天收集血浆用于分析雌激素、孕酮、LH和FSH。在四个明确定义的月经周期阶段中的每一个阶段评估饮食影响。分析卵泡早期血浆中的雄激素、皮质醇、甲状腺激素、胰岛素、PRL和性激素结合球蛋白。在围排卵期，低睾酮饮食降低LH（P = 0.009）和FSH（P = 0.04）水平。高睾酮饮食降低了卵泡早期的游离T-3（P = 0.02）和硫酸脱氢表雄酮（P = 0.02）水平，并降低了卵泡中期的雌酮水平（P = 0.02）。在激素浓度或月经周期、卵泡期或黄体期的长度方面没有观察到其他显著变化。在每个饮食周期的第3周期的黄体期进行的子宫内膜活检显示，食用维生素E对组织学测定没有影响。这些数据表明，对血浆激素和月经周期的影响不太可能是绝经前妇女预防癌症的主要机制。
Soy isoflavones are hypothesized to be responsible for changes in hormone action associated with reduced breast cancer risk. To test this hypothesis, we studied the effects of isoflavone consumption in 14 premenopausal women. Isoflavones were consumed in soy protein powders and provided relative to body weight (control diet, 10 +/- 1.1; low isoflavone diet, 64 +/- 9.2; high isoflavone diet, 128 +/- 16 mg/day) for three menstrual cycles plus 9 days in a randomized cross-over design. During the last 6 weeks of each diet period, plasma was collected every other day for analysis of estrogens, progesterone, LH, and FSH. Diet effects were assessed during each of four distinctly defined menstrual cycle phases. Plasma from the early follicular phase was analyzed for androgens, cortisol, thyroid hormones, insulin, PRL, and sex hormone-binding globulin. The low isoflavone diet decreased LH (P = 0.009) and FSH (P = 0.04) levels during the periovulatory phase. The high isoflavone diet decreased free T-3 (P = 0.02) and dehydroepiandrosterone sulfate (P = 0.02) levels during the early follicular phase and estrone levels during the midfollicular phase (P = 0.02). No other significant changes were observed in hormone concentrations or in the length of the menstrual cycle, follicular phase, or luteal phase. Endometrial biopsies performed in the luteal phase of cycle 3 of each diet period revealed no effect of isoflavone consumption on histological dating. These data suggest that effects on plasma hormones and the menstrual cycle are not likely to be the primary mechanisms by which isoflavones may prevent cancer in premenopausal women.