Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S
Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S
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DOI：
10.1016/j.chemosphere.2020.128009
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发表时间：
2021-01-01
期刊：
影响因子：
8.8
通讯作者：
Guzylack-Piriou, Laurence
中科院分区：
文献类型：
--
作者：
Brulport, Axelle;Lencina, Corinne;Guzylack-Piriou, Laurence
越来越多的证据突显了早期生活环境在塑造后代个人未来健康结果方面的关键作用。由于内分泌干扰物双酚A(BPA)的应用有限，双酚S(BPS)已被广泛用作各种塑料的替代品。然而，由于缺乏对BPS的有效评估，使得人们对BPA的相关替代品产生了怀疑。很少有关于跨代遗传的研究考察了环境暴露于内分泌干扰物对免疫系统的影响。在这项研究中，我们分析了BPS对肠道炎症的跨代影响及其在代谢方面的后果。在本研究中，只有F0孕鼠从妊娠第0天到仔鼠断奶期间暴露于BPS(1.5微克/千克体重/天)。在这项研究中，F1和F2雄性后代在成年后，在F0母亲接触BPS后，回肠和结肠都出现了炎症反应；这种现象在F3中消失了。在没有改变代谢状态的情况下，F1雄性后代的这种炎症反应与血胆固醇的显著降低有关。此外，在F3后代雄性中，肠道炎症反应的降低与脂肪重量的减少以及血糖和胆固醇水平的升高有关。在雌性后代中观察到一种特定性别的特征。我们还观察到，生命早期暴露于BPS与强烈的肠道免疫异常状态有关。这项研究表明，免疫系统和其他器官系统一样，容易受到环境暴露引起的跨代影响。(C)2020年由爱思唯尔有限公司出版。
Increasing evidence has highlighted the critical role of early life environment in shaping the future health outcomes of individuals in subsequent generations. Bisphenol S (BPS) has been widely used as a substitute for various plastic materials due to the limited application of Bisphenol A (BPA) which is an endocrine disruptor. However, the lack of efficient evaluation of BPS leaves doubts about the relevant substitute of BPA. Few studies of transgenerational inheritance have examined the effects of environmental exposures to endocrine disruptors on the immune system. In this study, we analyzed the transgenerational effects of BPS on intestinal inflammation and its consequence in metabolism. In this study, only F0 pregnant mice were exposed to BPS (1.5 mu g/kg bw/day) from gestational day 0 until weaning of offspring. In this work, both F1 and F2 male offspring developed an inflammatory response in the ileum and colon at adulthood after F0 mothers were exposed to BPS; this phenomenon disappeared in F3. This inflammatory response in F1 male offspring is associated with a significant decrease of blood cholesterol without modification of metabolic status. Further, in F3 offspring male, the decrease of gut inflammatory response is associated with a decrease of fat weight and with an increase of blood glucose and cholesterol level. A sex-specific profile is observed in female offspring. We also observed that early life exposure to BPS was associated with strong abnormal intestinal immune status. The study presented here demonstrates that the immune system, like other organ systems, is vulnerable to transgenerational effects caused by environmental exposures. (C) 2020 Published by Elsevier Ltd.