Temporal coding of taste in the parabrachial nucleus of the pons of the rat
Temporal coding of taste in the parabrachial nucleus of the pons of the rat
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DOI：
10.1152/jn.00836.2010
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发表时间：
2011-04-01
影响因子：
2.5
通讯作者：
Di Lorenzo, Patricia M.
中科院分区：
文献类型：
--
作者：
Rosen, Andrew M.;Victor, Jonathan D.;Di Lorenzo, Patricia M.
罗森AM，维克托JD，迪洛伦佐PM.大鼠脑桥臂旁核味觉的时间编码。神经生理学杂志105：1889-1896，2011年。首次发表于2011年2月9日; doi：10.1152/jn.00836.2010.-最近的研究表明，时间编码在味觉的第一个中枢--孤束核（NTS）对味觉刺激的编码有重要作用。然而，目前尚不清楚这种编码机制是否也用于中央味觉通路的下一个突触，脑桥臂旁核（PbN）。在本研究中，味觉刺激（蔗糖，氯化钠，盐酸，奎宁）的电生理反应记录从44个细胞在麻醉大鼠的PbN。在29个细胞中，评估了响应的时间特性对各种味觉品质的区分的贡献。使用了一系列指标来量化两个尖峰序列在尖峰计数和尖峰定时方面的相似性。结果表明，在14个PbN细胞（48%）的尖峰时间传达了大量的信息的味道质量，超出了可以单独通过尖峰计数传达。在另外14个细胞（48%）中，反应的速率包络（时间过程）比单独的尖峰计数贡献了更多的信息。在细胞间，调谐幅度与时间动力学传递的信息比例之间存在显著相关性（r = 0.51; P < 0.01）。与NTS（Di Lorenzo PM和维克托JD.神经生理学杂志90：1418-31，2003和J Neurophysiol 97：1857-1861，2007）显示，NTS中的时间编码发生在相似比例的细胞中，并且在相同的平均时间精度水平下贡献了总信息的相似部分，即使在PbN中试验间变异性高于NTS。这些数据表明，味觉质量的信息所传达的时间特性的诱发反应是高保真度从NTS的PbN。
Rosen AM, Victor JD, Di Lorenzo PM. Temporal coding of taste in the parabrachial nucleus of the pons of the rat. J Neurophysiol 105: 1889-1896, 2011. First published February 9, 2011; doi:10.1152/jn.00836.2010.-Recent studies have provided evidence that temporal coding contributes significantly to encoding taste stimuli at the first central relay for taste, the nucleus of the solitary tract (NTS). However, it is not known whether this coding mechanism is also used at the next synapse in the central taste pathway, the parabrachial nucleus of the pons (PbN). In the present study, electrophysiological responses to taste stimuli (sucrose, NaCl, HCl, and quinine) were recorded from 44 cells in the PbN of anesthetized rats. In 29 cells, the contribution of the temporal characteristics of the response to the discrimination of various taste qualities was assessed. A family of metrics that quantifies the similarity of two spike trains in terms of spike count and spike timing was used. Results showed that spike timing in 14 PbN cells (48%) conveyed a significant amount of information about taste quality, beyond what could be conveyed by spike count alone. In another 14 cells (48%), the rate envelope (time course) of the response contributed significantly more information than spike count alone. Across cells there was a significant correlation (r = 0.51; P < 0.01) between breadth of tuning and the proportion of information conveyed by temporal dynamics. Comparison with previous data from the NTS (Di Lorenzo PM and Victor JD. J Neurophysiol 90: 1418-31, 2003 and J Neurophysiol 97: 1857-1861, 2007) showed that temporal coding in the NTS occurred in a similar proportion of cells and contributed a similar fraction of the total information at the same average level of temporal precision, even though trial-to-trial variability was higher in the PbN than in the NTS. These data suggest that information about taste quality conveyed by the temporal characteristics of evoked responses is transmitted with high fidelity from the NTS to the PbN.