Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.
Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.
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DOI：
10.3389/fncel.2022.838007
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发表时间：
2022
影响因子：
5.3
通讯作者：
De Caro R
中科院分区：
文献类型：
--
作者：
Rivera AD;Azim K;Macchi V;Porzionato A;Butt AM;De Caro R
少突胶质细胞（OLs）是中枢神经系统轴突的特化胶质细胞。ol是由少突胶质细胞祖细胞（OPCs）通过一系列严格控制的分化步骤在整个生命过程中产生的。终身髓鞘形成对学习至关重要，并取代老年痴呆症（AD）和多发性硬化症（MS）等与年龄相关的疾病中髓鞘的丢失。值得注意的是，衰老的大脑中存在相当大的髓磷脂损失，这在AD中加速，并支持继发性进展性ms的髓鞘再生失败。与年龄相关的髓磷脂损失的一个重要因素是OPCs再生能力的显著下降。在这篇综述中，我们将介绍表皮生长因子（EGF）信号在调节少突胶质细胞多种生物通路中的关键作用，这些通路在衰老过程中失调。
Oligodendrocytes (OLs) are specialized glial cells that myelinate CNS axons. OLs are generated throughout life from oligodendrocyte progenitor cells (OPCs) via a series of tightly controlled differentiation steps. Life-long myelination is essential for learning and to replace myelin lost in age-related pathologies such as Alzheimer’s disease (AD) as well as white matter pathologies such as multiple sclerosis (MS). Notably, there is considerable myelin loss in the aging brain, which is accelerated in AD and underpins the failure of remyelination in secondary progressive MS. An important factor in age-related myelin loss is a marked decrease in the regenerative capacity of OPCs. In this review, we will contextualize recent advances in the key role of Epidermal Growth Factor (EGF) signaling in regulating multiple biological pathways in oligodendroglia that are dysregulated in aging.
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影响因子：
4.3
作者：
Azim K;Akkermann R;Cantone M;Vera J;Jadasz JJ;Küry P
通讯作者：
Küry P
影响因子：
9.8
作者：
Azim K;Angonin D;Marcy G;Pieropan F;Rivera A;Donega V;Cantù C;Williams G;Berninger B;Butt AM;Raineteau O
通讯作者：
Raineteau O
DOI：
10.1074/mcp.ra120.002102
发表时间：
2020-08
期刊：
Molecular & cellular proteomics : MCP
影响因子：
--
作者：
de la Fuente AG;Queiroz RML;Ghosh T;McMurran CE;Cubillos JF;Bergles DE;Fitzgerald DC;Jones CA;Lilley KS;Glover CP;Franklin RJM
通讯作者：
Franklin RJM
影响因子：
4.3
作者：
Cochard LM;Levros LC Jr;Joppé SE;Pratesi F;Aumont A;Fernandes KJL
通讯作者：
Fernandes KJL
影响因子：
2.4
作者：
Fünfschilling U;Saher G;Xiao L;Möbius W;Nave KA
通讯作者：
Nave KA