Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.
Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.
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在三种人胃癌细胞系中，高温诱导的细胞凋亡以 p53 基因依赖性和非依赖性方式发生。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Hisao Ito
中科院分区：
文献类型：
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作者：
A. Goto;K. Shomori;T. Ohkumo;F. Tanaka;Kenzo Sato;Hisao Ito
我们使用三种人胃癌细胞系，MKN-28（携带突变型p53基因），MKN-74（野生型）和KATO-III（完全缺失），研究了p53基因在高血压诱导的细胞凋亡中的作用。结果表明，i）长期高温导致坏死，短期治疗诱导凋亡，在一个渐进的时间依赖性的方式，ii）高血压触发的细胞凋亡可以发生在p53基因依赖和非依赖的方式，和iii）上调热休克蛋白70可能增强野生型p53蛋白在高血压诱导的细胞凋亡的功能。
We examined the role of the p53 gene in hyperthermia-induced apoptosis using three human gastric carcinoma cell lines, MKN-28 (carrying mutated type p53 gene), MKN-74 (wild-type), and KATO-III (complete deletion). The results indicate that i) long-term hyperthermia causes necrosis, and short-term treatment induces apoptosis in a gradual time dependent fashion, ii) hyperthermia-triggered apoptosis can occur both in a p53 gene-dependent and -independent manner, and iii) up-regulation of Hsp70 might enhance the function of wild-type p53 protein in hyperthermia-induced apoptosis.