Investigation into the physical stability of a eugenol nanoemulsion in the presence of a high content of triglyceride
Investigation into the physical stability of a eugenol nanoemulsion in the presence of a high content of triglyceride
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高甘油三酯含量下丁子香酚纳米乳液的物理稳定性研究
DOI：
10.1039/c6ra16270c
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Tian, Jing
中科院分区：
文献类型：
--
作者：
Chen, Huanle;Jin, Xing;Tian, Jing
研究了丁香酚（Eu）纳米乳液在具有高掺入比（在脂质相中为30重量%至80重量%）的长链和中链甘油三酯存在下的物理稳定性。通过动态光散射和基于离心力的LUMi-Sizer评估纳米乳液的稳定性。随着甘油三酯含量的增加，纳米乳的粒径先减小后增大。不同含量的甘油三酯存在下，颗粒大小的变化模式形成V型形状。60重量%甘油三酯的存在导致最小的粒度，其在储存的28天内继续增加。LUMi-Sizer分析表明，添加30-50重量%的甘油三酯引起的纳米乳液的不稳定性是由于乳液液滴的沉降。另一方面，由60-80重量%的甘油三酯引起的不稳定性是由于乳液液滴的漂浮。在相应的甘油三酯含量下，界面张力的变化趋势与粒径的变化趋势一致。因此，界面张力可能是负责的不稳定性的Eu纳米乳液的环糊精引起的。
The physical stability of a eugenol (Eu) nanoemulsion in the presence of long-chain and medium-chain triglycerides with a high incorporation ratio (30 wt% to 80 wt% in the lipid phase) was investigated. The stability of the nanoemulsion was evaluated by dynamic light scattering and a centrifugal-force-based LUMi-Sizer. With an increase in the content of triglycerides, the particle size of the nanoemulsions decreased first and then increased. The variation pattern of the particle size in the presence of different contents of triglycerides formed a V-type shape. The presence of 60 wt% triglycerides resulted in the smallest particle size, which continued increasing within 28 days of storage. LUMi-Sizer analyses demonstrated that the instability of the nanoemulsion caused by the addition of 30-50 wt% of triglyceride was due to sedimentation of emulsion droplets. On the other hand, the instability caused by 60-80 wt% of triglyceride was due to the floating of emulsion droplets. The interfacial tension variation had the same trend as the particle size variation at the corresponding content of triglycerides. Thus the interfacial tension might be responsible for the triglyceride-caused instability of the Eu nanoemulsion.