N400 amplitude reduction correlates with an increase in pupil size.
N400 amplitude reduction correlates with an increase in pupil size.
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DOI：
10.3389/fnhum.2011.00061
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发表时间：
2011
影响因子：
2.9
通讯作者：
Thierry G
中科院分区：
文献类型：
--
作者：
Kuipers JR;Thierry G
瞳孔扩张通常与人类认知负荷的增加有关。在这里，我们研究了人类瞳孔扩张和意义整合努力之间的潜在联系，这是由事件相关脑电位（ERPs）索引的。我们同时记录了受试者的瞳孔大小变化和erp，同时给他们看匹配的或不相关的图片-单词对。虽然言语和图片之间的意义相关性通常会调节erp，但在图片出现后，瞳孔大小也会迅速受到影响。此外，在与意义整合相关的时间窗内，瞳孔扩张越大，不相关图片引发的负N400振幅越小。由于瞳孔扩张与蓝斑-去甲肾上腺素（LC-NE）系统的活动有关，这些发现可能为人类高级认知功能与LC-NE系统活动之间的联系提供新的见解。
Pupil dilation is classically associated with increase in cognitive load in humans. Here, we studied the potential link between human pupil dilation and meaning integration effort as indexed by event-related brain potentials (ERPs). We recorded pupil size variation and ERPs simultaneously while participants were presented with matching or unrelated picture–word pairs. Whilst relatedness in meaning between spoken words and pictures typically modulated ERPs, pupil size was also affected quickly after picture onset. Moreover, during the time-window associated with meaning integration, greater pupil dilation correlated with less negative N400 amplitudes elicited by unrelated pictures. Since pupil dilation has been linked to activity of the locus coeruleus–norepinephrine (LC–NE) system, these findings may provide new insights into the suggested link between human high-level cognitive function and activity of the LC–NE system.