Pregnancy in patients with well-treated β-thalassemia:: Outcome for mothers and newborn infants
Pregnancy in patients with well-treated β-thalassemia:: Outcome for mothers and newborn infants
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DOI：
10.1016/s0002-9378(99)70214-0
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发表时间：
1999-02-01
影响因子：
9.8
通讯作者：
Karagiorga, M
中科院分区：
文献类型：
--
作者：
Aessopos, A;Karabatsos, F;Karagiorga, M
目的：我们的目的是调查的过程和结果，妊娠妇女治疗良好的β-地中海贫血。研究设计：22例妊娠，包括一个双胞胎妊娠，在19名妇女进行了研究。当患者接受了长时间的高输血和铁螯合强化治疗，并且超声心动图显示静息左心室功能正常时，建议妊娠。所有的概念都是自发的。在整个妊娠期和产后2 - 9年，对心脏功能沿着血液学、内分泌学和肝脏参数进行初步评估和监测。结果：共分娩健康新生儿21例。还发生了一起自然流产和一起外泌性流产。妊娠，分娩和恢复是令人惊讶的平安无事，并没有显着的心脏并发症，遇到.CONCLUSION：妊娠可以是安全的母亲和婴儿，地中海贫血的妇女已开始早期强化治疗，并有一个正常的静息心脏性能。
OBJECTIVE: Our purpose was to investigate the course and outcome of pregnancy in women with well-treated beta-thalassemia.STUDY DESIGN: Twenty-two pregnancies, including one twin pregnancy, in 19 women were studied. Pregnancy was advised when patients had received a prolonged intensive treatment with hypertransfusions and iron chelation and had echocardiographically normal resting left ventricular performance. All conceptions were spontaneous. Cardiac function, along with hematologic, endocrinologic, and hepatic parameters were initially assessed and monitored throughout pregnancy and for 2 to 9 years post: partum. Babies were delivered by elective cesarean section.RESULTS: Twenty-one healthy newborn infants were delivered. A spontaneous abortion and a case of exomphalos also occurred. Gestation, delivery, and recovery were surprisingly uneventful, and no significant cardiac complications were encountered.CONCLUSION: Pregnancy can be safe for mothers and babies, provided that women with thalassemia have been started early on intensive treatment and have a normal resting cardiac performance.