EFFECTS OF CHOLECYSTOKININ ON TASTE PREFERENCE AND SENSITIVITY IN RATS
EFFECTS OF CHOLECYSTOKININ ON TASTE PREFERENCE AND SENSITIVITY IN RATS
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DOI：
10.1037/0735-7044.98.3.452
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发表时间：
1984-01-01
影响因子：
1.9
通讯作者：
HSIAO, S
中科院分区：
文献类型：
--
作者：
GOSNELL, BA;HSIAO, S
Cholecystokinin octapeptide (CCK-8) reduced the amount consumed or the number of licks of several concentrations of sucrose in short-term tests with rats that were hungry, satiated, or fed ad lib. The suppressive effect of CCK-8 was generally smaller in the hungry than in the satiated or ad-lib condition. In the satiated and ad-lib conditions, there was no effect of sucrose concentration on the magnitude of the CCK-8 effect. In hungry rats, the concentration-intake function for sucrose was lowered and flattened by both CCK and natural satiety. To determine whether a taste change is involved in this short-term reduction of sucrose intake, integrated chorda tympani responses were measured before and after i.v. infusions of CCK-8 or NaCl. The peak response to 0.3 M sucrose significantly increased after two 5-.mu.g infusions of CCK-8. Peak and tonic responses to sucrose and saline tended to increase after CCK-8 but not NaCl infusions. CCK-8 apparently reduces sucrose intake in situations in which postingestional factors are minimal and that sucrose concentration has little effect on the size of this suppression. A change in perceived taste intensity or quality may play a role in the inhibitory effect of CCK-8 on intake.
