Duplication of large genomic regions during the evolution of vertebrate homeobox genes.
Duplication of large genomic regions during the evolution of vertebrate homeobox genes.
复制标题
脊椎动物同源盒基因进化过程中大基因组区域的复制。
DOI：
10.1073/pnas.86.18.7067
复制
发表时间：
1989
影响因子：
11.1
通讯作者：
Ruddle,FH
中科院分区：
文献类型：
--
作者：
Schughart,K;Kappen,C;Ruddle,FH
本文分析了21个小鼠Antp-class （Drosophila mutation Antennapedia-type class）同源盒基因的系统发育关系，并鉴定了几组相关基因。小鼠antp类同源盒基因定位在四个基因簇中。这四个基因簇的相似结构组织强烈表明，在一组相关的antp类同源异构体基因中，基因来源于大基因组区域的重复。在重复之后，同源盒基因簇的总体结构在很长一段进化时间内保持不变，这表明基因簇内的特定组织可能具有重要的功能。
The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that genes within a group of related Antp-class homeobox genes are derived from duplications of large genomic regions. After the duplication, the gross structures of the homeobox gene clusters have been maintained over a long period of evolutionary time, indicating that the specific organization of genes within a cluster may be of functional importance.