Effect of Depo-Provera® or Microgynon® on the painful crises of sickle cell anemia patients
Effect of Depo-Provera® or Microgynon® on the painful crises of sickle cell anemia patients
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DOI：
10.1016/s0010-7824(97)00156-x
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发表时间：
1997-11-01
期刊：
影响因子：
2.9
通讯作者：
Austin, KL
中科院分区：
文献类型：
--
作者：
de Abood, M;de Castillo, Z;Austin, KL
43例纯合子（SS）女性镰状细胞性贫血患者，每月至少有一次疼痛危象病史，并希望可逆避孕，每月给予DMPA/3个月或Microgynon（R）。第三组16名手术绝育的患者作为对照组。患者随访1年，以评估避孕药对患者疼痛危象的可能影响。在任何组中均未观察到血液学参数变化。在研究结束时，70%的接受甲氨蝶呤的患者没有疼痛，只有16%的仍报告疼痛危象的患者将其评定为强烈的。接受Microgynon的患者也有疼痛危象的改善，尽管速度较低; 12个月后，45.5%的患者仍经历了一些危象。虽然没有其他组那么明显，但50.5%的对照组患者也报告了他们的疼痛危象的改善，这可能是更密切的医疗护理的结果。(C)1997年爱思唯尔科学公司All rights reserved.
Forty-three homozygous (SS) female sickle cell anemic patients with a history of at least one painful crisis per month and desiring a reversible contraceptive were administered DMPA/3 months or Microgynon(R) monthly. A third group of 16 surgically sterilized patients served as control. Patients were followed for 1 year to assess possible effects of the contraceptives on the patients' painful crises. No changes were observed in any of the groups in the hematological parameters. At the end of the study, 70% of the patients receiving DMI)A were pain-free and only 16% of those still reporting painful crises rated them as intense Patients receiving Microgynon also had an amelioration of the painful crises, although at a lower rate; after 12 months, 45.5% still experienced some crises. Although less marked than in the other groups, 50.5% of the control patients also reported an improvement of their painful crisis, which may be a result of closer medical care. (C) 1997 Elsevier Science Inc. All rights reserved.