Cognitive functioning in children and adolescents with multiple sclerosis
Cognitive functioning in children and adolescents with multiple sclerosis
复制标题
DOI：
10.1212/01.wnl.0000158474.24191.bc
复制
发表时间：
2005-04-26
期刊：
影响因子：
9.9
通讯作者：
Krupp, LB
中科院分区：
文献类型：
--
作者：
MacAllister, WS;Belman, AL;Krupp, LB
目的：检测多发性硬化症(MS)患儿的认知功能。方法：对37例临床确诊为多发性硬化症的儿童进行神经心理学检查，评估认知功能与临床特征之间的关系。结果：在37名接受评估的儿童和青少年中，35%的人表现出明显的认知障碍。认知功能与几个临床变量密切相关，包括当前扩展的残疾状态量表、总复发次数和总病程。多发性硬化症的后果对超过三分之一的儿童的学习功能产生了不利影响。结论：多发性硬化症儿童存在认知缺陷。全面的治疗计划应该包括承认他们可能需要为他们的教育提供学术上的便利。
Objective: To examine cognitive functioning in children with multiple sclerosis ( MS). Methods: The authors examined the neuropsychological profile of 37 children with a diagnosis of clinically definite MS and assessed the associations between cognitive function and clinical features. Results: Of 37 children and adolescents evaluated, 35% demonstrated significant cognitive impairment. Cognitive functioning was strongly related to several clinical variables, including current Expanded Disability Status Scale, total number of relapses, and total disease length. The consequences of MS adversely affected academic functioning in over a third of the children. Conclusions: Cognitive deficits occur in children with multiple sclerosis. Comprehensive treatment planning should involve recognition that they may require academic accommodations for their education.