Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit
Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit
复制标题
蓝斑-上丘回路对先天防御反应的调节
DOI：
10.1177/1179069518792035
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发表时间：
2018-08
影响因子：
--
通讯作者：
Liping Wang
中科院分区：
文献类型：
--
作者：
Lei Li;Liping Wang
在关键的生存电路中，防御反应电路是研究最深入的电路之一。一个共识是，多个独立的电路参与不同的条件和非条件的防御反应。研究这些保守的防御反应将有助于我们在电路水平上破译大脑的基本工作机制，从而揭示神经疾病和障碍的新诊断和治疗方法。我们发现，视觉诱发的先天防御反应调制蓝斑上丘（LC-SC）的投射。我们的工作表明，作为保守和本能的生存电路，它们是灵活的，并受到经验或动物内部状态的微调调制。在这里，我们提供了更多的数据，以进一步讨论LC-SC通路的可能下游机制，这种重要的防御反应的调制，个人飞行反应之间的飞行潜伏期的广泛范围，以及我们的数据的解释与额外的统计分析。
Among key survival circuits, defensive response circuits are one of the most intensively studied. A consensus is emerging that multiple, independent circuitries are involved in different conditioned and unconditioned defensive responses. Investigating these well-conserved defensive responses would help us to decipher the basic working mechanism of the brain at a circuitry level and thus shed light on new diagnoses and treatments for neural diseases and disorders. We showed that the visually evoked innate defensive response was modulated by a locus coeruleus-superior colliculus (LC-SC) projection. Our work demonstrates that as conserved and instinctive as the survival circuits are, they are flexible and subject to fine-tuned modulation by experience or internal states of the animals. Here, we provide more data to further discuss the possible downstream mechanisms of the LC-SC pathway for this important modulation of the defensive response, the wide range of flight latency between individual flight responses, and the interpretations of our data with additional statistical analysis.
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DOI：
10.1016/j.cub.2017.03.031
发表时间：
2017-05-08
期刊：
Current biology : CB
影响因子：
--
作者：
Vale R;Evans DA;Branco T
通讯作者：
Branco T
影响因子：
9.2
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
64.5
作者：
Zelikowsky M;Hui M;Karigo T;Choe A;Yang B;Blanco MR;Beadle K;Gradinaru V;Deverman BE;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
34.7
作者：
P. Tovote;J. Fadok;A. Lüthi
通讯作者：
P. Tovote;J. Fadok;A. Lüthi
不同的中脑回路协调小鼠对迫在眉睫的刺激的逃避和冻结反应
影响因子：
16.6
作者：
Shang C;Chen Z;Liu A;Li Y;Zhang J;Qu B;Yan F;Zhang Y;Liu W;Liu Z;Guo X;Li D;Wang Y;Cao P
通讯作者：
Cao P