Antiviral Activity of Resveratrol against Human and Animal Viruses.
Antiviral Activity of Resveratrol against Human and Animal Viruses.
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DOI：
10.1155/2015/184241
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发表时间：
2015
影响因子：
2.2
通讯作者：
Noordin MM
中科院分区：
文献类型：
--
作者：
Abba Y;Hassim H;Hamzah H;Noordin MM
白藜芦醇是一种有效的多酚类化合物，在体外和体内都被广泛研究用于改善病毒感染。其抗氧化作用主要通过抑制重要的基因途径如NF-κβ途径来引起，而其抗病毒作用与抑制病毒复制、蛋白质合成、基因表达和核酸合成有关。虽然白藜芦醇在几种病毒性疾病中的有益作用已经得到了很好的证明，但也有一些不良反应的报道。这篇综述强调了白藜芦醇在人类和动物病毒感染中的抗病毒机制，以及其中一些作用如何与该化合物的抗氧化特性相关。
Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. This review highlights the antiviral mechanisms of resveratrol in human and animal viral infections and how some of these effects are associated with the antioxidant properties of the compound.