Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
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DOI：
10.1016/s0022-3956(03)00095-5
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发表时间：
2004-01-01
影响因子：
4.8
通讯作者：
Mathalon, DH
中科院分区：
文献类型：
--
作者：
Ford, JM;Mathalon, DH
推论放电的失败，是一种区分自我产生的知觉和外部产生的知觉的机制，被认为是精神分裂症某些阳性症状的基础，包括幻听。虽然最初在视觉系统中描述，但必然放电可能存在于听觉系统中，由此来自运动语音命令的信号为自我生成的语音准备听觉皮层。虽然与感觉运动系统有关，但它也可能适用于内部言语或思想，被认为是我们最复杂的运动行为。我们在本文总结的研究中有四个目标：（1）用事件相关脑电位（ERPs）证明人类志愿者在谈话和内部言语中的必然放电现象，（2）证明精神分裂症患者的必然放电是异常的，（3）证明额叶言语区在谈话中的必然放电中的作用，（4）将精神分裂症的伴随放电功能障碍与幻听联系起来。使用EEG和ERP的措施，我们解决了精神分裂症患者（DSM IV）和健康对照组的每个目标。NI组件的ERP反映了阻尼的听觉皮层的反应，在交谈和内部语言在对照组，但不是在患者。EEG的连贯性措施表明，在对照组的谈话过程中，额叶语音产生和颞叶语音接收区的活动相互依赖，但在患者中，尤其是那些产生幻觉的患者。这些数据表明，产生思想的额叶区域的必然放电无法提醒听觉皮质它们是自发的，导致内部言语错误地归因于外部来源并产生幻听的体验。(C)2003 Elsevier Ltd.保留所有权利。
Failure of corollary discharge, a mechanism for distinguishing self-generated from externally-generated percepts, has been posited to underlie certain positive symptoms of schizophrenia, including auditory hallucinations. Although originally described in the visual system, corollary discharge may exist in the auditory system, whereby signals from motor speech commands prepare auditory cortex for self-generated speech. While associated with sensorimotor systems, it might also apply to inner speech or thought, regarded as our most complex motor act. We had four aims in the studies summarized in this paper: (1) to demonstrate the corollary discharge phenomenon during talking and inner speech in human volunteers using event-related brain potentials (ERPs), (2) to demonstrate that the corollary discharge is abnormal in patients with schizophrenia, (3) to demonstrate the role of frontal speech areas in the corollary discharge during talking, and (4) to relate the dysfunction of the corollary discharge in schizophrenia to auditory hallucinations. Using EEG and ERP measures, we addressed each aim in patients with schizophrenia (DSM IV) and healthy control subjects. The NI component of the ERP reflected dampening of auditory cortex responsivity during talking and inner speech in control subjects but not in patients. EEG measures of coherence indicated inter-dependence of activity in the frontal speech production and temporal speech reception areas during talking in control subjects, but not in patients, especially those who hallucinated. These data suggest that a corollary discharge from frontal areas where thoughts are generated fails to alert auditory cortex that they are self-generated, leading to the misattribution of inner speech to external sources and producing the experience of auditory hallucinations. (C) 2003 Elsevier Ltd. All rights reserved.