FOCUSED US SYSTEM FOR MR IMAGING-GUIDED TUMOR ABLATION
FOCUSED US SYSTEM FOR MR IMAGING-GUIDED TUMOR ABLATION
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DOI：
10.1148/radiology.194.3.7862971
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发表时间：
1995-03-01
期刊：
影响因子：
19.7
通讯作者：
JOLESZ, FA
中科院分区：
文献类型：
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作者：
CLINE, HE;HYNYNEN, K;JOLESZ, FA
目的：测量用于磁共振 (MR) 成像引导肿瘤消融的聚焦超声 (US) 系统的性能特征。材料和方法：作者构建了用于 MR 成像引导肿瘤消融的聚焦超声 (US) 系统。在施加每个声脉冲后，通过在体模和兔子骨骼肌中获得的温度敏感 MR 图像来监测加热区域的位置和热剂量。结果：聚焦超声波束加热的区域与在体内兔子骨骼肌的温度敏感快速梯度回波 MR 图像上观察到的区域在 1 mm 以内。热流和凝固性坏死率的分析提供了对消融区域大小的估计，这与实验结果一致。结论：MR 成像为灌注可变区域或特征不明确的组织中的热治疗提供了目标定义和控制。
PURPOSE: To measure the performance characteristics of a focused ultrasound (US) system for magnetic resonance (MR) imaging-guided tumor ablation.MATERIALS AND METHODS: The authors constructed a focused US system for MR imaging-guided tumor ablation. The location of the heated region and thermal dose were monitored with temperature-sensitive MR images obtained in phantoms and rabbit skeletal muscle after application of each sonic pulse.RESULTS: The region heated by the focused ultrasound beam was within 1 mm of that observed on temperature-sensitive fast gradient-echo MR images of in vivo rabbit skeletal muscle. Analysis of heat flow and the rate of coagulation necrosis provided an estimate of the size of the ablated region that was in agreement with experimental findings.CONCLUSION: MR imaging provides target definition and control for thermal therapy in regions of variable perfusion or in tissues that are not well characterized.