Flow Cytometry: A Multipurpose Technology for a Wide Spectrum of Global Biosecurity Applications
Flow Cytometry: A Multipurpose Technology for a Wide Spectrum of Global Biosecurity Applications
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DOI：
10.1016/j.jala.2009.03.001
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发表时间：
2009-06-01
期刊：
影响因子：
--
通讯作者：
Marrone, Babetta L.
中科院分区：
文献类型：
--
作者：
Marrone, Babetta L.
流式细胞术及其后代流分选对于与传染病相关的生物安全和公共卫生研究来说是非常有用的技术。应用范围从病原体的环境监测到诊断以及开发用于预防和控制传染病的疫苗和疗法。流式细胞仪专为实验室分析和现场部署而开发。如果仪器和数据分析变得更简单并具有更多自动化功能，并且如果技术得到改进以减少与感染性生物体分析和分类相关的生物安全问题，那么当前的技术水平可以得到更广泛的应用。流式细胞术技术应对全球生物安全挑战的全部可能应用尚未实现。 （贾拉 2009；14：148-56）
Flow cytometry, and its offspring-flow sorting, are extremely useful technologies for biosecurity and public health studies related to infectious disease. Applications range from environmental surveillance of pathogens to diagnosis and the development of vaccines and therapeutics for prevention and control of infectious diseases. Flow cytometers have been developed for laboratory analysis and field deployment. The current state of the art could enjoy more widespread use if instruments and data analysis were made simpler and had more automated functions, and if technology was modified to reduce biosafety concerns related to analysis and sorting of infectious organisms. The full spectrum of possible applications of flow cytometry technology to global biosecurity challenges has not yet been realized. (JALA 2009;14:148-56)