Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations.
Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations.
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DOI：
10.1001/archderm.1990.01670270083013
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发表时间：
1990-03
影响因子：
--
通讯作者：
G. Fierlbeck;G. Rassner;C. Müller
中科院分区：
文献类型：
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作者：
G. Fierlbeck;G. Rassner;C. Müller
用于治疗银屑病关节炎的重组人干扰素γ可诱导注射部位的角质形成细胞表达人类白细胞抗原DR，但不能诱导表达人类白细胞抗原DP或DQ。部分患者关节症状有所改善，但皮肤表现未受影响。在42例患者中，有10例在注射干扰素-γ的部位可形成点状银屑病灶。在本报告中，我们选择了一名患有银屑病关节病和II型糖尿病的女性患者，在应用干扰素伽马的部位诱发银屑病，而不是在皮下注射胰岛素或安慰剂之后。结论：干扰素-γ是银屑病发生发展过程中的重要淋巴因子。
Recombinant human interferon gamma used for treatment of psoriatic arthritis was found to induce expression of HLA-DR, but not HLA-DP or HLA-DQ, on keratinocytes at the site of injection. Some patients showed an improvement of their joint symptoms, but the cutaneous manifestations remained unaffected. In 10 of 42 patients, punctiform psoriatic foci could be induced at the site of injection of interferon gamma. For this presentation, we selected a female patient with psoriatic arthropathy and type II diabetes mellitus in whom psoriasis was induced at the site of application of interferon gamma, but not after subcutaneous injection of insulin or placebo. We conclude that interferon gamma is an important lymphokine in the development of psoriasis.