A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation.
A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation.
复制标题
在记忆巩固过程中，齿状回-CA3抑制电路促进了海马区-大脑皮层整体的进化。
DOI：
10.7554/elife.70586
复制
发表时间：
2022-02-22
期刊：
影响因子：
7.7
通讯作者：
Sahay A
中科院分区：
文献类型：
--
作者：
Twarkowski H;Steininger V;Kim MJ;Sahay A
在海马的齿状回（DG）-CA 3回路中编码的记忆从CA 1路由到前扣带皮层（ACC）进行巩固。虽然CA 1小白蛋白抑制神经元（PVINs）协调大脑皮层-皮层的通信，我们知道的很少关于CA 3 PVINs或DG CA 3主要神经元的PVINs电路机制，有助于在记忆巩固过程中的大脑皮层-皮层合奏的演变。使用病毒遗传学选择性地模拟和促进内源性学习依赖性电路机制，DG细胞招募CA 3 PV IN和前馈抑制（FFI）在CA 3中，结合纵向体内钙成像，我们证明FFI促进CA 1中上下文相关神经元集合的形成和维持。随着时间的推移，增加DG CA 3中的FFI促进了ACC中神经元集合的上下文特异性，并增强了长期的上下文恐惧记忆。在体内LFP记录与增加的FFI在DG CA 3的小鼠确定增强CA 1的尖锐波涟漪ACC纺锤体耦合作为一个潜在的网络机制，促进记忆巩固。我们的研究结果阐明了如何FFI在DG CA 3支配的整体性能在CA 1和ACC的记忆巩固过程中的演变，并提出了教师样的功能，海马CA 1区的稳定和重组的皮层代表。
Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1 parvalbumin inhibitory neurons (PV INs) orchestrate hippocampal-cortical communication, we know less about CA3 PV INs or DG ‒ CA3 principal neuron ‒ IN circuit mechanisms that contribute to evolution of hippocampal-cortical ensembles during memory consolidation. Using viral genetics to selectively mimic and boost an endogenous learning-dependent circuit mechanism, DG cell recruitment of CA3 PV INs and feed-forward inhibition (FFI) in CA3, in combination with longitudinal in vivo calcium imaging, we demonstrate that FFI facilitates formation and maintenance of context-associated neuronal ensembles in CA1. Increasing FFI in DG ‒ CA3 promoted context specificity of neuronal ensembles in ACC over time and enhanced long-term contextual fear memory. In vivo LFP recordings in mice with increased FFI in DG ‒ CA3 identified enhanced CA1 sharp-wave ripple ‒ ACC spindle coupling as a potential network mechanism facilitating memory consolidation. Our findings illuminate how FFI in DG ‒ CA3 dictates evolution of ensemble properties in CA1 and ACC during memory consolidation and suggest a teacher-like function for hippocampal CA1 in stabilization and re-organization of cortical representations.