Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery
Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery
复制标题
DOI：
10.1034/j.1600-0412.2001.080009803.x
复制
发表时间：
2001-09-01
影响因子：
4.3
通讯作者：
Klebe, JG
中科院分区：
文献类型：
--
作者：
Lauszus, FF;Gron, PL;Klebe, JG
的目标。遗传环境是血管内皮细胞功能障碍的潜在危险因素。亚甲基四氢叶酸还原酶（MTHFR）基因（677C- >T）多态性在合并子痫前期、肾病、视网膜病变和早产的糖尿病妊娠中的患病率进行了评估。高同型半胱氨酸血症在糖尿病微血管病变中的作用一直存在争议，主要表现为MTHFR基因活性降低。MTHFR基因的多态性被确定为导致这种现象。研究人员招募了268名患有I型糖尿病的孕妇。我们成功地分析了233名妇女的MTHFR基因多态性677C—>T，并比较了该多态性在背景人群中的发病率（n=1084）。回顾性分析妊娠资料图表。MTHFR多态性的频率。背景人群杂合度为29%，杂合度为42%。1型糖尿病女性的MTHFR多态性频率为52%杂合子和9%纯合子，高于背景人群(杂合子，背景与1型糖尿病：chi (2)= 14, df=1, p
Aim. The genetic setting is a potential risk factor for dysfunction of vascular endothelial cells. The prevalence of polymorphism in the methylene-tetrahydro-folate-reductase (MTHFR) gene (677C-->T) was evaluated in diabetic pregnancy complicated by preeclampsia, nephropathy, retinopathy, and preterm delivery. The role of hyperhomocysteinemia in microangiopathy in diabetes mellitus has been debated and is mainly seen with reduced activity of the MTHFR gene. A polymorphism in the gene for MTHFR is identified causing this phenomenon.Design. Two hundred and sixty-eight pregnant women with type I diabetes mellitus were recruited. Two hundred and thirty-three women were successfully analyzed for MTHFR gene polymorphism 677C-->T and compared to the incidence of the polymorphism in the background population (n=1084). The pregnancy data charts were reviewed retrospectively.Results. The frequency of the MTHFR polymorphism. in the background population was 29% and the heterozygozity 42%. The women with type I diabetes mellitus had a higher frequency of the MTHFR polymorphism with 52% heterozygotes and 9% homozygotes than had the background population (heterozygotes, background vs. type I diabetes mellitus: chi (2)= 14, df=1, p