Expression of the BCL6 gene in the pre- and postnatal mouse
Expression of the BCL6 gene in the pre- and postnatal mouse
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DOI：
10.1006/bbrc.1998.8551
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发表时间：
1998-06-18
影响因子：
3.1
通讯作者：
Lagercrantz, J
中科院分区：
文献类型：
--
作者：
Bajalica-Lagercrantz, S;Piehl, F;Lagercrantz, J
人BCL6，也称为LAZ3，是一种参与基因调控的蛋白质，BCL6的异常表达与非霍奇金淋巴瘤的肿瘤发生有关。我们利用原位杂交组织化学和Northern印迹法分析了小鼠bcl6在出生前和出生后的表达情况。在14天胚胎中，鼻腔内发育中的嗅上皮是唯一显示bcl6 mRNA阳性信号的组织。在妊娠第17天，表达主要见于骨骼肌、嗅上皮和胸腺，也见于上呼吸道和食管的上皮。在出生后小鼠的特定组织中，在脑、肾皮质、脾和胸腺中检测到bcl6表达。在脑中的表达局限于大脑皮质的锥体细胞层以及海马CA1和CA2区以及齿状回。我们的结果表明，bcl6的表达并不局限于淋巴系统的器官，如脾和胸腺。因此，bcl6可能在许多不同细胞类型（包括上皮细胞和神经细胞）中作为基因转录的调节因子发挥作用。（C）1998年学术出版社。
Human BCL6, also called LAZ3, is a protein involved in gene regulation and abnormal expression of BCL6 and has been implicated in the tumorigenesis of non-Hodgkin lymphoma. We have analyzed the expression of murin bcl6 in pre- and postnatal mouse using in situ hybridization histochemistry and Northern blotting. The developing olfactory epithelium in the nasal cavity was the only tissue displaying a positive bcl6 mRNA signal in the day 14 embryo. At gestational day 17, expression was primarily seen in skeletal muscle, olfactory epithelium, and thymus, and also in the epithelium lining the upper airways and esophagus, In selected tissues from postnatal mouse, bcl6 expression was detected in brain, renal cortex, spleen, and thymus, The expression in brain was restricted to the pyramidal cell layer of the cerebral cortex and the hippocampus regions CA1 and CA2, and the dentate gyrus. Our results show that bcl6 expression is not confined only to organs of the lymphatic system, such as spleen and thymus, Thus, bcl6 may be active as a regulator of gene transcription in many different cell types, including epithelial and nerve cells. (C) 1998 Academic Press.