B-type natriuretic peptide (BNP) affects the initial response to intravenous glucose: a randomised placebo-controlled cross-over study in healthy men
B-type natriuretic peptide (BNP) affects the initial response to intravenous glucose: a randomised placebo-controlled cross-over study in healthy men
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DOI：
10.1007/s00125-011-2392-1
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发表时间：
2012-05-01
期刊：
影响因子：
8.2
通讯作者：
Clodi, M.
中科院分区：
文献类型：
--
作者：
Heinisch, B. B.;Vila, G.;Clodi, M.
目的/假设 B 型钠尿肽 (BNP) 是心肌细胞响应细胞拉伸而释放的一种激素，并在心力衰竭时升高。最近的观察表明慢性心力衰竭和糖尿病之间存在明显的联系。本研究调查了 BNP 对葡萄糖代谢的作用。 方法 招募 10 名健康志愿者（25+/-1 岁；BMI 23+/-1 kg/m(2)；空腹血糖 4.6+/-0.1 mmol/l）参加在大学医学中心进行的一项参与者盲法研究者开放式安慰剂对照交叉研究。他们被随机分配（按顺序编号的不透明密封信封）接受安慰剂或在研究第1天或第2天的4小时内静脉注射3 pmol kg(-1) min(-1) BNP-32。开始BNP/安慰剂输注一小时后，进行3小时静脉内葡萄糖耐量试验（20分钟时0.33 g/kg葡萄糖+ 0.03 U/kg胰岛素）。经常测量血浆葡萄糖、胰岛素和C肽。结果每组分析10名志愿者。 BNP 增加了初始葡萄糖分布体积（13+/-1% 体重 vs 11+/-1%，p
Aims/hypothesis B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism.Methods Ten healthy volunteers (25+/-1 years; BMI 23+/-1 kg/m(2); fasting glucose 4.6+/-0.1 mmol/l) were recruited to a participant-blinded investigator-open placebo-controlled cross-over study, performed at a university medical centre. They were randomly assigned (sequentially numbered opaque sealed envelopes) to receive either placebo or 3 pmol kg(-1) min(-1) BNP-32 intravenously during 4 h on study day 1 or 2. One hour after beginning the BNP/placebo infusion, a 3 h intravenous glucose tolerance test (0.33 g/kg glucose + 0.03 U/kg insulin at 20 min) was performed. Plasma glucose, insulin and C-peptide were frequently measured.Results Ten volunteers per group were analysed. BNP increased the initial glucose distribution volume (13+/-1% body weight vs 11+/-1%, p