Genetic correlation between innate alcohol preference and fear-potentiated startle in selected mouse lines
Genetic correlation between innate alcohol preference and fear-potentiated startle in selected mouse lines
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DOI：
10.1111/j.1530-0277.2007.00396.x
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发表时间：
2007-07-01
影响因子：
3.2
通讯作者：
Chester, Julia A.
中科院分区：
文献类型：
--
作者：
Barrenha, Gustavo D.;Chester, Julia A.
背景：在人类中，焦虑和酒精使用障碍的共现率很高，这可能源于共同基因的遗传，从而增加了患这两种精神疾病的风险。本研究的目的是研究先天酒精偏好与习得性恐惧倾向之间是否存在遗传关系，采用恐惧增强惊吓（FPS）范式，在2个选择性培养高或低酒精偏好的小鼠品系中进行研究。方法：从选择性繁殖的高酒精偏好和低酒精偏好的重复对系中，随机将未接触酒精的雄性和雌性小鼠分配到恐惧条件组或对照组。恐惧条件组的小鼠接受了20对光刺激和足震；对照组接受相同数量的光和足震暴露，除了这些刺激明显是不配对的。在FPS测试中，声音刺激在有光刺激和没有光刺激的情况下都被呈现。结果：在两个重复对系中，选择高酒精偏好的小鼠比选择低酒精偏好的小鼠表现出更高的FPS。在所有品系中均未发现FPS的性别差异。对照组未出现FPS。结论：这些发现表明，在这些选定的小鼠品系中，共同基因介导先天酒精偏好和习得性恐惧倾向。
Background: There is a high rate of co-occurrence between anxiety and alcohol-use disorders in humans that may arise from the inheritance of common genes that increase the risk for both psychiatric disorders. The purpose of this study was to investigate whether a genetic relationship exists between innate alcohol preference and propensity to develop learned fear, using the fear-potentiated startle (FPS) paradigm, in 2 mouse lines selectively bred for high or low alcohol preference.Methods: Alcohol-naive, male, and female mice from replicate pairs of lines selectively bred for high alcohol preference and low alcohol preference were randomly assigned to a fear-conditioned or control group. Mice in the fear-conditioned group received 20 pairings of a light stimulus and footshock; the control group received the same number of exposures to light and footshock, except that these stimuli were explicitly unpaired. During testing for FPS, acoustic stimuli were presented both in the presence and in the absence of the light stimulus.Results: In both replicate pairs of lines, mice selectively bred for high alcohol preference showed greater FPS than mice selectively bred for low alcohol preference. No sex differences in FPS were found in any line. Control groups did not show FPS.Conclusion: These findings suggest that common genes mediate both innate alcohol preference and propensity to develop learned fear in these selected mouse lines.