Aggregation-Induced Emission Active Metal-Free Chemosensing Platform for Highly Selective Turn-On Sensing and Bioimaging of Pyrophosphate Anion
Aggregation-Induced Emission Active Metal-Free Chemosensing Platform for Highly Selective Turn-On Sensing and Bioimaging of Pyrophosphate Anion
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DOI：
10.1021/acs.analchem.5b01746
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发表时间：
2015-07-07
影响因子：
7.4
通讯作者：
Das, Gopal
中科院分区：
文献类型：
--
作者：
Gogoi, Abhijit;Mukherjee, Sandipan;Das, Gopal
我们报道了一种无金属化学传感器的合成，用于在生理介质中高度选择性地感应焦磷酸盐（PPi）阴离子。新型苯基苯并咪唑功能化亚胺含化学传感器（L;[2,6-双（（（4-（1h -苯并-[d]咪唑-2-基）苯基）亚胺）甲基）-4甲基苯酚]）可以在非常竞争的环境中通过“开启”比色和荧光反应感应PPi阴离子。整个传感机制是基于聚集诱导发射（ALE）现象。此外，通过检测l涂层纸条中的PPi，演示了实时现场设备的应用。有趣的是，通过荧光显微镜研究也可以检测模型人类细胞中的细胞内PPi离子，而不会对这些细胞产生任何毒性
We report the synthesis of a metal-free chemosensor for highly selective sensing of pyrophosphate (PPi) anion in physiological medium. The novel phenylbenzimidazole functionalized imine containing chemosensor (L; [2,6-bis(((4-(1H-benzo-[d]imidazol-2-yl)phenyl)imino) methyl)-4 methyl phenol]) could sense PPi anion through "turn-on" colorimetric and fluorimetric responses in a very competitive environment. The overall sensing mechanism is based on the aggregation-induced emission (ALE) phenomenon. Moreover, a real time in-field device application was demonstrated by sensing PPi in paper strips coated with L. Interestingly, detection of intracellular PPi ions in model human cells could also be possible by fluorescence microscopic studies without any toxicity to these