Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: Diffusion tensor imaging
Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: Diffusion tensor imaging
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DOI：
10.1038/sj.npp.1300617
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发表时间：
2005-03-01
影响因子：
7.6
通讯作者：
Narayana, PA
中科院分区：
文献类型：
--
作者：
Moeller, FG;Hasan, KM;Narayana, PA
大脑成像研究发现可卡因依赖者前额叶皮质功能障碍的证据。同样，可卡因依赖者也有与执行功能和冲动有关的行为问题。由于前额叶皮质轴突束在胼胝体中的两个半球之间交叉，因此在可卡因依赖的受试者中，胼胝体中的白色物质完整性也可能减少。本研究的目的是比较胼胝体白色物质的完整性，测量的分数各向异性（FA）的扩散张量成像（DTI）之间的18个可卡因依赖的主题和18个健康对照。Barratt冲动量表（BIS-11）和连续操作测试：即时和延迟记忆任务（IMT/DMT）也被收集。DTI结果显示，可卡因依赖受试者与对照组相比，胼胝体前部的头侧和喙侧体的FA显著降低。可卡因依赖的受试者也有显着较高的BIS-11评分，更大的冲动（委员会）的错误，并降低能力，区分目标从捕捉刺激（辨别力）的IMT/DMT。在可卡因依赖的受试者有一个显着的负相关FA在胼胝体前部和行为实验室测量的冲动，有一个正相关FA和辨别力。可卡因使用者胼胝体前部白色物质的完整性降低与冲动控制受损和区分目标和捕捉刺激的能力降低有关，这一发现与可卡因依赖受试者额叶皮质参与抑制控制受损的先前理论一致。
Brain imaging studies find evidence of prefrontal cortical dysfunction in cocaine-dependent subjects. Similarly, cocaine-dependent subjects have problems with behaviors related to executive function and impulsivity. Since prefrontal cortical axonal tracts cross between hemispheres in the corpus callosum, it is possible that white matter integrity in the corpus callosum could also be diminished in cocaine-dependent subjects. The purpose of this study was to compare corpus callosum white matter integrity as measured by the fractional anisotropy ( FA) on diffusion tensor imaging (DTI) between 18 cocaine-dependent subjects and 18 healthy controls. The Barratt Impulsiveness Scale (BIS-11) and a continuous performance test: the Immediate and Delayed Memory Task (IMT/DMT) were also collected. Results of the DTI showed significantly reduced FA in the genu and rostral body of the anterior corpus callosum in cocaine-dependent subjects compared to controls. Cocaine-dependent subjects also had significantly higher BIS-11 scores, greater impulsive ( commission) errors, and reduced ability to discriminate target from catch stimuli (discriminability) on the IMT/DMT. Within cocaine dependent subjects there was a significant negative correlation between FA in the anterior corpus callosum and behavioral laboratory measured impulsivity, and there was a positive correlation between FA and discriminability. The finding that reduced integrity of anterior corpus callosum white matter in cocaine users is related to impaired impulse control and reduced ability to discriminate between target and catch stimuli is consistent with prior theories regarding frontal cortical involvement in impaired inhibitory control in cocaine-dependent subjects.