MYASTHENIA-GRAVIS - POPULATION DIFFERENCES IN DISEASE EXPRESSION AND ACETYLCHOLINE-RECEPTOR ANTIBODY-TITERS BETWEEN CHINESE AND CAUCASIANS
MYASTHENIA-GRAVIS - POPULATION DIFFERENCES IN DISEASE EXPRESSION AND ACETYLCHOLINE-RECEPTOR ANTIBODY-TITERS BETWEEN CHINESE AND CAUCASIANS
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DOI：
10.1212/wnl.37.12.1854
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发表时间：
1987-12-01
期刊：
影响因子：
9.9
通讯作者：
HUNG, TP
中科院分区：
文献类型：
--
作者：
CHIU, HC;VINCENT, A;HUNG, TP
比较了中国人（n = 258）和高加索人（n = 258）重症肌无力人群的临床特征和抗乙酰胆碱受体（AChR）滴度。前者早发和眼部病例较多，缺乏白种人晚发高峰，重症病例较少。抗AChR窝的分布在两个人群中大致相似，他们的血清反应同样良好，在两个种族的AChR。中国人群中显著较低（ψ 2 = 14.6; p < 0.001）的中值抗AChR滴度可以由眼部病例的较高频率和中度或严重受累病例的较低频率来解释。
Clinical features and anti-acetylcholine receptor (AChR) titers were compared in Chinese (n = 258) and Caucasian (n = 258) myasthenia gravis populations. The former had more early onset and ocular cases, lacked the Caucasian late onset peak, and had fewer severe cases. The distribution of anti-AChR litters was broadly similar in the two populations, and their sera reacted equally well with AChR in both races. The significantly lower (.psi.2 = 14.6; p < 0.001) median anti-AChR titer in the Chinese population can be accounted for by the higher frequency of ocular cases and lower frequency of moderate or severely affected cases.