Cadherins and mechanotransduction by hair cells.
Cadherins and mechanotransduction by hair cells.
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DOI：
10.1016/j.ceb.2008.06.004
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发表时间：
2008-10
影响因子：
7.5
通讯作者：
Müller U
中科院分区：
文献类型：
--
作者：
Müller U
机械传导，将机械刺激转换为电信号，对我们的听觉和保持平衡的能力至关重要。最近的研究结果表明，钙粘蛋白超家族的两个成员是脊椎动物内耳感觉毛细胞的机械转导机制的组成部分。这些研究表明，钙粘蛋白23（CDH23）和原钙粘蛋白15（PCDH15）形成几个细胞外丝，将毛细胞的静纤毛和动纤毛连接成一束。这些细丝之一是尖端链接，已被提议用于门控毛细胞中的机械转导通道。CDH23和PCDH15的胞外结构域与经典钙粘蛋白的结构不同，它们的胞质结构域与不同的效应物结合，这表明进化压力塑造了这两种钙粘蛋白在机械转导中的功能。
Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal is critical for our ability to hear and to maintain balance. Recent findings indicate that two members of the cadherin superfamily are components of the mechanotransduction machinery in sensory hair cells of the vertebrate inner ear. These studies show that cadherin 23 (CDH23) and protocadherin 15 (PCDH15) form several of the extracellular filaments that connect the stereocilia and kinocilium of a hair cell into a bundle. One of these filaments is the tip link that has been proposed to gate the mechanotransduction channel in hair cells. The extracellular domains of CDH23 and PCDH15 differ in their structure from classical cadherins and their cytoplasmic domains bind to distinct effectors, suggesting that evolutionary pressures have shaped the two cadherins for their function in mechanotransduction.
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