Nitric oxide and the respiratory enzyme
Nitric oxide and the respiratory enzyme
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DOI：
10.1016/j.bbabio.2006.05.011
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发表时间：
2006-09-01
影响因子：
4.3
通讯作者：
Sarti, Paolo
中科院分区：
文献类型：
--
作者：
Brunori, Maurizio;Forte, Elena;Sarti, Paolo
综述了关于一氧化氮(NO)控制呼吸酶(细胞色素-C-氧化酶)活性的分子机制的现有信息。我们报道，根据绝对电子通量的不同，生理浓度的NO通过两种不同的反应途径可逆地抑制细胞色素-c-氧化酶，产生亚硝酰-或亚硝酸盐-血红素a(3)衍生物。我们提出了一些假设，设想了NO和细胞色素-c-氧化酶之间的反应的生理和/或病理效应。(C)2006爱思唯尔B.V.保留所有权利。
Available information on the molecular mechanisms by which nitric oxide (NO) controls the activity of the respiratory enzyme (cytochrome-c-oxidase) is reviewed. We report that, depending on absolute electron flux, NO at physiological concentrations reversibly inhibits cytochrome-c-oxidase by two alternative reaction pathways, yielding either a nitrosyl- or a nitrite-heme a(3) derivative. We address a number of hypotheses, envisaging physiological and/or pathological effects of the reactions between NO and cytochrome-c-oxidase. (c) 2006 Elsevier B.V. All rights reserved.