Two-Dimensional CFD based compartment modeling for dynamic simulation of semi-batch crystallization processes in stirred tank reactors
Two-Dimensional CFD based compartment modeling for dynamic simulation of semi-batch crystallization processes in stirred tank reactors
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DOI：
10.1016/j.compchemeng.2020.106933
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
T. Maßmann;C. Kocks;Leonhard Parakenings;B. Weber;A. Jupke
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文献类型：
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作者：
T. Maßmann;C. Kocks;Leonhard Parakenings;B. Weber;A. Jupke
结晶过程的特点是投加一个或多个饲料往往占主导地位的局部现象，在进料位置。本工作应用计算流体动力学（CFD）为基础的隔室模型（CM）的pH值变化结晶的衣康酸与两个饲料占不均匀性。通过时间驱动的n-Monte-Carlo建模解决每个隔室中的种群平衡。根据文献进行分区和模型验证。CFD模拟忽略了进料体积流量和CM的影响，没有应用从CM到CFD的反馈回路。这项工作显示了强烈变化的填充水平（高达63%），从而流动制度的应用。局部相对过饱和的隔间是必要的获得的实验数据的解释（Eggert等人，2019年）。对于相对于168 h− 1 m −2的平均种子表面积的相对过饱和度的变化率，必须考虑局部分辨率。
Crystallization processes whose characteristic is dosing of one or multiple feeds are often dominated by local phenomena at the feeding positions. This work applies a computational fluid dynamics (CFD) based compartment model (CM) to pH-shift crystallization of itaconic acid with two feeds to account for inhomogeneities. Population balancing in each compartment is solved by time-driven n-Monte-Carlo modeling. Compartmentation and model validation is performed according to literature. The influence of the feed volume flow and CM is neglected for CFD simulation, no feedback loop from CM to CFD is applied. This work shows the application for strongly changing filling levels (up to 63%) and thereby flow regimes. Local relative supersaturations of compartments are necessary for the interpretation of obtained experimental data by (Eggert et al., 2019). Local resolution has to be considered for change rates of the relative supersaturation with respect to mean seed surface area over 168 h−1m−2.