Effects of Phosphate Deprivation on Carbohydrate Metabolism*
Effects of Phosphate Deprivation on Carbohydrate Metabolism*
复制标题
缺磷对碳水化合物代谢的影响*
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
R. Kalkhoff
中科院分区：
文献类型：
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作者：
W. Marshall;M. Banasiak;R. Kalkhoff
测试同时对营养，等热量的液体配方，并再次后10-14天的相同饮食缺乏磷酸盐。在这后一时期，全身磷酸盐损失先前已显示为平均1.5 mmol/kg体重。血清磷浓度从1.30 ±.04mM降至1.03 ±.07mM（P < 0.01），而血清钙浓度无明显变化。磷酸盐剥夺不会改变基础葡萄糖或胰岛素浓度。然而，在Lv后5、10和20分钟，血浆胰岛素增量增加25-65%。观察到葡萄糖推注（25克）（P < 0.05），而血浆葡萄糖曲线没有变化。此外，总血浆胰岛素对LV的反应。缺磷期血糖升高30%（P < 0.05）。静脉注射甲苯磺丁脲（1 g）对葡萄糖反应没有影响，也没有引起高胰岛素血症。我们的结论是，短期缺磷可使血浆胰岛素对Lv的反应过度。在原发性甲状旁腺功能亢进中观察到的葡萄糖，可能导致这种情况下发现的内源性胰岛素抵抗。
tests while on a nutritious, isocaloric liquid formula and again after 10-14 days of the same diet devoid of phosphate. During this latter period total body phosphate loss has previously been shown to average 1.5 mmol/kg body weight. The serum phos phate fell significantly from 1.30 ± .04 mM to 1.03 ± .07 mM (p < 0.01) with no change in serum calcium concentra tion. Phosphate deprivation did not alter basal glucose or in sulin concentrations. However, 25-65% increases of plasma insulin increments at 5, 10 and 20 minutes after an Lv. glu cose bolus (25 grams) were observed (p < 0.05) without change in plasma glucose curves. Moreover, total plasma in sulin responses to LV. glucose were 30% greater during the per iod of phosphate deprivation (p < 0.05). Intravenous tol butamide (1 g) produced no changes in glucose responses and failed to elicit hyperinsulinemia. We conclude that short term phosphate deprivation repro duces the exaggerated plasma insulin response to Lv. glucose that is observed in primary hyperparathyroidism and may contribute to endogenous insulin resistance found in this condition.