Synthesis and biological evaluation of manzamine analogues.
Synthesis and biological evaluation of manzamine analogues.
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DOI：
10.1021/ol061320b
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发表时间：
2006-07
期刊：
影响因子：
5.2
通讯作者：
J. Winkler;Allyn T. Londregan;Justin R. Ragains;M. Hamann
中科院分区：
文献类型：
--
作者：
J. Winkler;Allyn T. Londregan;Justin R. Ragains;M. Hamann
【结构：描述了代表五环ABCDE二胺核部分结构的一系列manzamine A类似物的合成和生物学评价。所有新化合物都经过了抗恶性疟原虫的筛选，显示出相对于曼扎明A减弱的抗疟活性。
[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.