Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females
Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females
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DOI：
10.1113/ep085642
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发表时间：
2016-04-01
影响因子：
2.7
通讯作者：
Budge, Helen
中科院分区：
文献类型：
--
作者：
Robinson, Lindsay J.;Law, James M.;Budge, Helen
新发现本研究的中心问题是什么？心理压力，这是众所周知的促进皮质醇分泌，同时激活棕色脂肪组织的功能，在健康的成年女性？主要发现及其重要性是什么？棕色脂肪组织（brown adipose tissue，BAT）与肥胖、2型糖尿病和代谢综合征的发病机制有关，是一个潜在的治疗靶点。棕色脂肪组织可以通过解偶联蛋白1的作用对能量平衡和葡萄糖稳态产生重大影响，在神经内分泌刺激后将化学能作为热量耗散。我们假设，心理压力，这是已知的促进皮质醇分泌，将同时激活BAT在热中性。棕色脂肪组织的活动进行了测量，使用红外热成像，以确定覆盖锁骨上BAT（T-SCR）的皮肤的温度变化。一个温和的心理压力，诱导五个健康，瘦，女性，高加索志愿者使用一个简短的心算（MA）测试。将T-SCR与重复评估进行比较，其中MA测试被一段时间的放松所取代。虽然MA没有引起急性应激反应，MA测试的预期导致唾液皮质醇的增加，表明预期的应激反应，这与更高的绝对和相对T-SCR的趋势。T-SCR和皮质醇之间的正相关性被发现在预期阶段，一种关系，这是增强与MA的皮质醇增加。我们的研究结果表明，心理压力水平的微妙变化可以刺激BAT，这可能是报告BAT患病率和其他方式测量的活动的高度可变性和不一致性的原因。对这种独特的代谢组织的一致评估是发现针对代谢性疾病的潜在治疗策略的基础。
New FindingsWhat is the central question of this study? Does psychological stress, which is known to promote cortisol secretion, simultaneously activate brown adipose tissue function in healthy adult females?What is the main finding and its importance? One explanation for the pronounced differences in brown adipose tissue function between individuals lies in their responsiveness to psychological stress and, as such, should be taken into account when examining its in vivo stimulation.Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeostasis through the action of uncoupling protein1, dissipating chemical energy as heat following neuroendocrine stimulation. We hypothesized that psychological stress, which is known to promote cortisol secretion, would simultaneously activate BAT at thermoneutrality. Brown adipose tissue activity was measured using infrared thermography to determine changes in the temperature of the skin overlying supraclavicular BAT (T-SCR). A mild psychological stress was induced in five healthy, lean, female, Caucasian volunteers using a short mental arithmetic (MA) test. The T-SCR was compared with a repeated assessment, in which the MA test was replaced with a period of relaxation. Although MA did not elicit an acute stress response, anticipation of MA testing led to an increase in salivary cortisol, indicative of an anticipatory stress response, that was associated with a trend towards higher absolute and relative T-SCR. A positive correlation between T-SCR and cortisol was found during the anticipatory phase, a relationship that was enhanced by increased cortisol linked to MA. Our findings suggest that subtle changes in the level of psychological stress can stimulate BAT, findings that may account for the high variability and inconsistency in reported BAT prevalence and activity measured by other modalities. Consistent assessment of this uniquely metabolic tissue is fundamental to the discovery of potential therapeutic strategies against metabolic disease.