The JNK signal transduction pathway
The JNK signal transduction pathway
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DOI：
10.1016/j.ceb.2007.02.001
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发表时间：
2007-04-01
影响因子：
7.5
通讯作者：
Davis, Roger J.
中科院分区：
文献类型：
--
作者：
Weston, Claire R.;Davis, Roger J.
c-Jun氨基末端激酶（JNK）是丝裂原活化蛋白（MAP）激酶的进化上保守的亚组。最近的研究提高了我们对JNK通路的生理功能的理解。参与JNK通路的新分子的作用已经被定义，并且已经实现了对JNK在存活信号传导、细胞死亡、癌症和糖尿病中的作用的新见解。
The c-Jun NH2-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding of the physiological function of the JNK pathway. Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival signaling, cell death, cancer and diabetes has been achieved.