Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China.
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China.
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DOI：
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发表时间：
1994-07
影响因子：
4.7
通讯作者：
D. Hensrud;D. Heimburger;J. Chen;B. Parpia
中科院分区：
文献类型：
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作者：
D. Hensrud;D. Heimburger;J. Chen;B. Parpia
目的研究抗氧化状态与心血管疾病（CVD：冠心病、高血压性心脏病和中风）和克山病死亡率的关系。设计生态研究。研究对象：中华人民共和国65个主要为农村的县。对象从两个公社（6500名受试者）中随机选择每个县100名受试者。干预抗氧化剂，抗氧化酶，和促氧化剂从性别和社区特定的血液样本在每个县进行了测量。测定红细胞脂肪酸含量。死亡率由全国死亡率调查确定。结果：在单变量分析中，抗氧化状态与CVD死亡率之间的相关性在统计学上并不显著，尽管血浆抗坏血酸、β-胡萝卜素和视黄醇与CVD死亡率始终呈负相关。血浆抗坏血酸与脑卒中死亡率呈显著负相关（r =-0.38，P < 0.01），血浆硒与克山病死亡率呈显著负相关（r =-0.32，P < 0.05）。血浆铜与高血压性心脏病死亡率呈显著正相关（r = 0.32，P < 0.05）。此前报道的该人群的数据表明，红细胞单不饱和脂肪酸与心血管疾病死亡率之间呈负相关，而红细胞多不饱和脂肪酸与心血管疾病死亡率之间呈直接相关。结论心血管病和克山病的死亡率与红细胞脂肪酸含量和血液中抗氧化状态的某些指标有关。据推测，脂肪酸和CVD之间的关联可能与低密度脂蛋白中所含的相应脂肪酸对氧化的不同敏感性有关。
OBJECTIVE Various measures of antioxidant status were investigated in relation to mortality from cardiovascular disease (CVD: coronary heart disease, hypertensive heart disease, and stroke) and Keshan disease. DESIGN Ecological study. SETTING Sixty-five largely rural counties in the People's Republic of China. SUBJECTS One hundred subjects in each county randomly selected from two communes (6500 subjects). INTERVENTIONS Antioxidants, antioxidant enzymes, and pro-oxidants were measured from sex- and commune-specific pooled blood samples in each county. Fatty acid content of red blood cells was measured. Mortality rates were determined from a national mortality survey. RESULTS In univariate analysis most correlations between measures of antioxidant status and mortality rates from CVD were not statistically significant, although plasma ascorbic acid, beta-carotene and retinol were consistently inversely associated with CVD mortality rates. There were significant negative associations between plasma ascorbic acid and mortality from stroke (r = -0.38, P < 0.01), and plasma selenium and mortality from Keshan disease (r = -0.32, P < 0.05). There was a significant positive association between plasma copper and mortality from hypertensive heart disease (r = 0.32, P < 0.05). Data previously reported from this population demonstrated an inverse association between red blood cell monounsaturated fatty acids and mortality from CVD, and a direct association between red blood cell polyunsaturated fatty acids and mortality from CVD. CONCLUSIONS Mortality from CVD and Keshan disease is associated with the fatty acid content of red blood cells and some measures of antioxidant status in blood. It is postulated that the associations between fatty acids and CVD may be related to the different susceptibilities of the respective fatty acids, contained in low-density lipoprotein, to oxidation.