Perceived stress at work is associated with attenuated DHEA-S response during acute psychosocial stress
Perceived stress at work is associated with attenuated DHEA-S response during acute psychosocial stress
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DOI：
10.1016/j.psyneuen.2013.01.010
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发表时间：
2013-09-01
影响因子：
3.7
通讯作者：
Jonsdottir, Ingibjorg H.
中科院分区：
文献类型：
--
作者：
Lennartsson, Anna-Karin;Theorell, Tores;Jonsdottir, Ingibjorg H.
背景：脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEA- s）被认为在急性社会心理应激中起保护作用，因为它们可以作为应激激素皮质醇的拮抗剂。本研究旨在调查在过去一周的工作中，长期的社会心理压力是否与急性社会心理压力期间产生脱氢表雄酮和脱氢表雄酮- s的能力有关。它还旨在调查在急性社会心理压力期间，长期的感知压力是否影响皮质醇和DHEA-S的产生之间的平衡。方法：健康受试者36例，男19例，女17例，平均年龄37岁，SD 5岁。使用压力-能量（SE）问卷对过去一周的工作压力进行测量。参与者根据平均得分分为三组；低压力，中等压力和高压力。接受特里尔社会压力测试（TSST），并在压力测试前、测试后和恢复后30分钟采集血样。使用一般线性模型来研究中等应激组和高应激组与低应激组相比在应激反应方面是否存在差异。结果：在急性社会心理应激期间，较高的工作感知压力与DHEA-S反应减弱有关。此外，在急性压力测试中，报告高感知工作压力的个体比报告低感知工作压力的个体皮质醇产生和DHEA-S产生的比率更高。两组间DHEA反应无统计学差异。结论：本研究表明，在过去一周的工作中，长时间的压力似乎会对急性压力下产生DHEA-S的能力产生负面影响。考虑到DHEA-S的保护功能，急性应激期间DHEA-S的减少可能导致心理和生理健康不良影响的风险更高，特别是如果应激持续暴露。(C) 2013 Elsevier Ltd.版权所有。
Background: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to play a protective role during acute psychosocial stress, because they act as antagonists to the effects of the stress hormone cortisol. This study aims to investigate whether prolonged psychosocial stress, measured as perceived stress at work during the past week, is related to the capacity to produce DHEA and DHEA-S during acute psychosocial stress. It also aims to investigate whether prolonged perceived stress affects the balance between production of cortisol and DHEA-S during acute psychosocial stress.Method: Thirty-six healthy subjects (19 men and 17 women, mean age 37 years, SD 5 years), were included. Perceived stress at work during the past week was measured by using the Stress-Energy (SE) Questionnaire. The participants were divided into three groups based on their mean scores; Low stress, Medium stress and High stress. The participants underwent the Trier Social Stress Test (TSST) and blood samples were collected before, directly after the stress test, and after 30 min of recovery. General Linear Models were used to investigate if the Medium stress group and the High stress group differ regarding stress response compared to the Low stress group.Results: Higher perceived stress at work was associated with attenuated DHEA-S response during acute psychosocial stress. Furthermore, the ratio between the cortisol production and the DHEA-S production during the acute stress test were higher in individuals reporting higher perceived stress at work compared to individuals reporting low perceived stress at work. There was no statistical difference in DHEA response between the groups.Conclusions: This study shows that prolonged stress, measured as perceived stress at work during the past week, seems to negatively affect the capacity to produce DHEA-S during acute stress. Given the protective functions of DHEA-S, attenuated DHEA-S production during acute stress may Lead to higher risk for adverse effects on psychological and physiological health, particularly if stress exposure continues. (C) 2013 Elsevier Ltd. All rights reserved.