Detection of Neural Signals with Vertically Grown Single Platinum Nanowire-Nanobud
Detection of Neural Signals with Vertically Grown Single Platinum Nanowire-Nanobud
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DOI：
10.1166/jnn.2009.1462
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发表时间：
2009-11-01
影响因子：
--
通讯作者：
Leung, M.
中科院分区：
文献类型：
--
作者：
Choi, D. S.;Fung, A. O.;Leung, M.
我们开发了一种纳米级的神经探测装置，用于体外检测神经活动。采用聚焦离子束化学气相沉积(FIB)-化学气相沉积(CVD)技术在微电极阵列上制备了单根垂直铂纳米线，以提高记录的空间分辨率，并将对电池的损伤降至最低。在电极阵列上培养大鼠成神经细胞。与细胞接触的电极检测到显著的自发电活动。我们的实验证明，纳米探针可以实时检测神经细胞中的电生理信号。
We developed a nanoscale neural probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Rat neuroblasts were cultured on the electrode array. Electrodes in contact with cells detected prominent spontaneous electrical activity. Our experiments demonstrate the nanoprobes for the real-time detection of electrophysiological signals in neuronal cells.