Designing drug-loaded multi-layered polymeric microparticles
Designing drug-loaded multi-layered polymeric microparticles
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DOI：
10.1007/s10856-011-4508-z
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发表时间：
2012-01-01
影响因子：
3.7
通讯作者：
Loo, Say Chye Joachim
中科院分区：
文献类型：
--
作者：
Lee, Wei Li;Widjaja, Effendi;Loo, Say Chye Joachim
本工作报告了如何通过简单、经济、可靠和通用的一步溶剂蒸发方法制备包含不混溶聚合物的新型多层（从双层到四层）微粒。这些多层微粒将是克服用于药物递送的单层微粒中固有的问题的优秀候选物。通过扫描电子显微镜和拉曼映射确定颗粒形态、层配置和药物分布。确定了实现多层结构形成的关键工艺参数。多种药物的封装和这些药物在这些多层微粒内的层定位也已被证明是可能的，这是由药物-聚合物亲和力驱动的。因此，这种一步制造技术可用于定制颗粒设计，从而促进多颗粒药物递送装置的开发。
This work reports how novel multi-layered (from double-layered to quadruple-layered) microparticles comprising immiscible polymers can be fabricated through a simple, economical, reliable and versatile one-step solvent evaporation method. These multi-layered microparticles would be excellent candidates to overcome problems inherent in single-layered microparticles for drug delivery. Particle morphologies, layer configurations, and drug distribution were determined by scanning electron microscopy and Raman mapping. Key process parameters achieving the formation of the multi-layered structure were identified. Encapsulation of multiple drugs and layer localization of these drugs within these multi-layered microparticles have also shown to be possible, which were driven by drug-polymer affinity. This one-step fabrication technique can therefore be used for tailoring particle designs, thus facilitating the development of multiparticulate drug delivery devices.