Dissecting the NUP107 complex Multiple components and even more functions
Dissecting the NUP107 complex Multiple components and even more functions
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DOI：
10.4161/nucl.21135
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发表时间：
2012-07-01
期刊：
影响因子：
3.7
通讯作者：
Askjaer, Peter
中科院分区：
文献类型：
--
作者：
Gonzalez-Aguilera, Cristina;Askjaer, Peter
核孔复合物（NPC）是一个迷人的结构，其功能的相关性和复杂性吸引了显着的兴趣。在NPC中，几个不同的亚复合物相互作用，形成高度保守和稳定的结构。NUP 107复合体是其中一个亚复合体，由7-9个成员组成。NUP 107复合物具有多种功能，从NPC组装到mRNA输出到细胞分化。最近，NUP 107复合物的遗传解剖为复合物的组装提供了新的见解，并且还揭示了与有丝分裂纺锤体组装检查点蛋白MAD 1的意想不到的联系。
The nuclear pore complex (NPC) is a fascinating structure whose functional relevance and complexity attract significant interest. Within the NPC, several different subcomplexes interact with each other to form a highly conserved and stable structure. One of these subcomplexes is the NUP107 complex, constituted by 7-9 members. A wide variety of functions have been ascribed to the NUP107 complex, ranging from NPC assembly to mRNA export to cell differentiation. Recently, genetic dissection of the NUP107 complex has provided novel insight to the assembly of the complex and has, moreover, revealed an unexpected connection with the mitotic spindle assembly checkpoint protein MAD1.