Anticonvulsant and hypnotic effects of amiodarone
Anticonvulsant and hypnotic effects of amiodarone
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DOI：
10.1631/jzus.b0820316
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发表时间：
2009-04-01
影响因子：
5.1
通讯作者：
Bakirci, Aysegul
中科院分区：
文献类型：
--
作者：
Ozbakis-Dengiz, Gunnur;Bakirci, Aysegul
胺碘酮盐酸盐是一种有效的抗心律失常剂，被称为心脏中的多离子通道阻滞剂。尽管已在大鼠大脑中检测到它，但尚无与其中枢神经系统（CNS）影响相关的数据。在这项研究中，我们评估了胺碘酮的抗惊厥和催眠作用。苯四唑（PTZ）（100 mg/kg）或咖啡因（300 mg/kg）诱导小鼠惊厥。在这两种模型中，胺碘酮延长了潜伏期和死亡时间，并起到抗惊厥药物的作用。发现在 PTZ 模型中比在咖啡因模型中更有效；在 PTZ 模型中，用 150 mg/kg 剂量胺碘酮治疗的动物均未死亡。为了获得催眠效果，用戊巴比妥（35 mg/kg）诱导大鼠睡眠。胺碘酮剂量依赖性地增加了睡眠时间（677.7%～725.9%）。睡眠试验中200mg/kg胺碘酮组大鼠全部死亡。总之，胺碘酮的抗惊厥和催眠作用已显示出对中枢神经系统的抑制作用。这些作用可能取决于其药理学特性。
Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%similar to 725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties.