Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers
Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers
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阿霉素与多糖组装微胶囊作为高效抗癌药物载体
DOI：
10.1002/adhm.201200414
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发表时间：
2013-09-01
影响因子：
10
通讯作者：
Li, Junbai
中科院分区：
文献类型：
--
作者：
Du, Cuiling;Zhao, Jie;Li, Junbai
以阿霉素和改性海藻酸钠为壁材，采用模板法自交联制备微胶囊。所制备的微胶囊具有pH响应性。相关的扫描电子显微镜，原子力显微镜和共聚焦激光扫描显微镜证实了均匀的微胶囊的形态。光谱分析结果表明，微胶囊是通过静电相互作用和席夫碱共价键组装而成。在较低pH值的缓冲溶液中，阿霉素可从胶囊中持续释放。微囊的细胞摄取和酸性微环境诱导的药物释放是时间依赖性的过程。体外细胞毒性实验表明，阿霉素微囊对肿瘤细胞有较强的杀伤作用。
Doxorubicin, together with the modified polysaccharide (alginate dialdehyde), was used as a wall material to fabricate microcapsules through self-cross-linking by a template method. The microcapsules as-prepared are pH-responsive. Relevant scanning electronic microscopy, atom force microscopy and confocal laser scanning microscopy confirm the morphology of the uniform microcapsules. The spectroscopic results show that the microcapsules are assembled through electrostatic interaction and Schiff's base covalent bonding. Doxorubicin can be released sustainably from the capsules in buffer solution at a lower pH value. The cellular uptake of the microcapsules and drug release induced by acidic microenvironment are time-dependent processes. The cell cytotoxicity experiments in vitro demonstrate that the doxorubicin-based microcapsules have high efficiency to kill the cancer cells.