THE ROLE OF THE LIVER IN THE TURNOVER OF PLASMA CHOLESTEROL
THE ROLE OF THE LIVER IN THE TURNOVER OF PLASMA CHOLESTEROL
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DOI：
10.1016/0003-9861(55)90330-1
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发表时间：
1955-01-01
影响因子：
3.9
通讯作者：
CHAIKOFF, IL
中科院分区：
文献类型：
--
作者：
HOTTA, S;CHAIKOFF, IL
将胆固醇与胆固醇-4-C14混合后标记的胆固醇静脉注射到大鼠体内，并在注射后18至90小时的不同时间间隔测定从血浆中分离的总胆固醇的比活度。从正常大鼠血浆中分离的总胆固醇的比活性-时间曲线在半对数纸上绘制为直线。在将肝脏从循环中排除后，从血浆中分离的总胆固醇的周转突然停止。从血浆中分离的总胆固醇的周转时间约为60小时。
Cholesterol labeled by admixture with cholesterol-4-C14 was injected intravenously into rats, and the specific activity of total cholesterol isolated from plasma was determined at various intervals from 18 to 90 hours after the injections. The specific activity-time curves for total cholesterol isolated from plasma of normal rats were straight lines when plotted on semilogarithmic paper. Following exclusion of the liver from the circulation, the turnover of total cholesterol isolated from plasma ceased abruptly. The turnover time for total cholesterol isolated from plasma was about 60 hours.