The effect of plasma proteins on the interaction of platelets with glass surfaces.
The effect of plasma proteins on the interaction of platelets with glass surfaces.
复制标题
血浆蛋白对血小板与玻璃表面相互作用的影响。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
Mustard Jf
中科院分区：
文献类型：
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作者：
M. Packham;M. Packham;G. Evans;G. Evans;Glynn Mf;Glynn Mf;Mustard Jf;Mustard Jf
试管的白蛋白涂层提供了血小板几乎不粘附的表面。纤维蛋白原涂层导致血小板粘附于表面，但很少释放血小板内容物。相比之下，γ球蛋白包被引起血小板成分的粘附、聚集和广泛释放。玻璃的硅涂层对血小板与表面的相互作用几乎没有影响，但是在悬浮洗涤血小板的介质中存在明胶会降低血小板与表面的粘附性，尽管它不会降低由γ球蛋白涂层管诱导的血小板内容物的释放程度。
Abstract Albumin-coating of tubes provides a surface to which platelets have little tendency to adhere. Fibrinogen-coating leads to platelet adherence to the surface, but little release of platelet contents. In contrast, gamma globulin-coating causes adherence, aggregation, and extensive release of platelet constituents. Silicone-coating of glass has little effect on the interaction of platelets with the surface, but the presence of gelatin in the medium in which washed platelets are suspended decreases the adherence of platelets to surfaces, although it does not diminish the extent of release of platelet contents induced by gamma globulin-coated tubes.