Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women.
Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women.
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DOI：
10.1186/1471-2334-14-152
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发表时间：
2014-03-21
影响因子：
3.7
通讯作者：
Minakami H
中科院分区：
文献类型：
--
作者：
Yamada T;Mochizuki J;Hanaoka M;Hashimoto E;Ohkuchi A;Ito M;Kubo T;Nakai A;Saito S;Unno N;Matsubara S;Minakami H
日本在过去十年（2004年和2012 - 2013年）经历了两次风疹疫情，分别导致10名和20名婴儿患有先天性风疹综合征（CRS）。 本研究旨在确定日本经产妇女的血清阴性率是否低于经产妇女。回顾性分析了5年研究期间（2008年1月至2012年12月）在日本北方6家医院分娩的11048例经产妇和9315例经产妇的妊娠期血凝抑制（HI）试验结果。 以血凝抑制（HI）滴度<1：8为风疹易感人群。 年龄在30 - 31岁（2.3% [22/967] vs. 4.5% [66/1454]，P = 0.0036）、36 - 37岁（3.4% [55/1601] vs. 5.7% [79/1389]，P = 0.0030）和总体女性（34.7 ± 5.2岁3.8% [350/9315] vs. 5.4% [597/11048]，33.2 ± 5.9，P <0.001）的经产女性血清阴性率显著低于经产女性。 不同医院的易感分数大小差异不大，范围为3.5%至6.3%。每年的这些数据没有明显变化; 2008年、2009年、2010年、2011年和2012年分别为4.5%[150/3369]、5.2% [221/4268]、4.4% [195/4412]、4.6% [186/4056]和4.6% [195/4258]。青少年的比例一直很高：2008年、2009年、2010年、2011年和2012年分别为22.7% [5/22]、20.7% [6/29]、20.6% [7/34]、13.0% [3/23]和23.5% [4/17]。血清阴性率显着低于经产妇女。然而，日本的风疹疫苗接种计划不足以消除CRS。
Japan experienced two rubella outbreaks in the past decade (2004 and 2012 – 2013), resulting in 10 and 20 infants with congenital rubella syndrome (CRS), respectively. This study was performed to determine whether the seronegative rate was lower in multiparous women than in primiparous women in Japan. Hemagglutination inhibition (HI) test results during pregnancy were analyzed retrospectively in 11048 primiparous and 9315 multiparous women who gave birth at six hospitals in northern Japan in the 5-year study period (January 2008 through December 2012). Women with HI titer < 1:8 were defined as susceptible to rubella. The seronegative rate was significantly lower in multiparous than primiparous women aged 30 – 31 years (2.3% [22/967] vs. 4.5% [66/1454], P = 0.0036), 36 – 37 years (3.4% [55/1601] vs. 5.7% [79/1389], P = 0.0030), and overall women (3.8% [350/9315] aged 34.7 ± 5.2 vs. 5.4% [597/11048] for 33.2 ± 5.9, P < 0.001). The susceptible fraction size did not differ largely according to hospital, ranging from 3.5% to 6.3%. Those for each year did not change markedly; 4.5% [150/3369], 5.2% [221/4268], 4.4% [195/4412], 4.6% [186/4056], and 4.6% [195/4258] for 2008, 2009, 2010, 2011, and 2012, respectively. Those for teenagers were consistently high: 22.7% [5/22], 20.7% [6/29], 20.6% [7/34], 13.0% [3/23], and 23.5% [4/17] for 2008, 2009, 2010, 2011, and 2012, respectively. The seronegative rate was significantly lower in multiparous than primiparous women. However, Japanese rubella vaccination programs were insufficient to eliminate CRS.
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影响因子：
6.4
作者：
Castillo-Solórzano, C;Carrasco, P;de Quadros, CA
通讯作者：
de Quadros, CA
影响因子：
4.5
作者：
Babigumira JB;Morgan I;Levin A
通讯作者：
Levin A
DOI：
10.1111/j.1447-0756.2011.01653.x
发表时间：
2011-09-01
影响因子：
1.6
作者：
Minakami, Hisanori;Hiramatsu, Yuji;Yoshikawa, Hiroyuki
通讯作者：
Yoshikawa, Hiroyuki
影响因子：
4.2
作者：
GALAZKA, A
通讯作者：
GALAZKA, A
DOI：
10.1111/j.1447-0756.2007.00689.x
发表时间：
2008-04-01
影响因子：
1.6
作者：
Okuda, Mika;Yamanaka, Michiko;Hirahara, Fumiki
通讯作者：
Hirahara, Fumiki