Kinetic studies of thyroxine, 3,5,3'-triiodothyronine, 3,3,5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine in patients with liver cirrhosis.
Kinetic studies of thyroxine, 3,5,3'-triiodothyronine, 3,3,5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine in patients with liver cirrhosis.
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肝硬化患者中甲状腺素、3,5,3-三碘甲状腺原氨酸、3,3,5-三碘甲状腺原氨酸、3,5-二碘甲状腺原氨酸、3,3-二碘甲状腺原氨酸和 3-单碘甲状腺原氨酸的动力学研究。
DOI：
10.1210/jcem-53-5-978
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
T. Friis
中科院分区：
文献类型：
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作者：
J. Faber;H. F. Thomsen;I. B. Lumholtz;C. Kirkegaard;K. Siersbaek;T. Friis
采用单次注射非房室方法，对10例酒精性肝硬化患者和9例甲状腺功能正常的健康对照者进行了T4、T3、rT 3、3 '，5'-二碘甲状腺原氨酸（3 '，5'-T2）、3，3 '-二碘甲状腺原氨酸（3，3'-T2）和3 '-单碘甲状腺原氨酸（3'-T1）的转换研究。在同一个体中研究了所有6种碘甲腺原氨酸的动力学。一种新开发的，简单的和可重复的凝胶分离技术，然后通过抗体提取，用于血清中示踪剂的定量。肝硬化患者血清T_4、T_3和3，3 ′-T_2水平降低，而血清rT_3和3 ′，5 ′-T_2水平升高，3 ′-T_1水平无变化。观察到MCR降低的总体趋势。以下中位MCR（升/天/70 kg BW）（抗凝剂vs.对照）：T4，1.13 vs. 1.19（P = NS）; T3，16 vs. 20（P <0.05）; rT3，81 vs. 147（P小于0.01）; 3 '，5'-T2，131对279（P小于0.01）; 3，3 '-T2，533对1116（P小于0.01）;和3'-T1，375对539（P小于0.05）。T4、rT 3和3，5 '-T2的产生率（纳摩尔/天/70 kg BW）在肝硬化患者中未发生显著变化（肝硬化组与对照组）：分别为100 vs. 117、47.5 vs. 52.0和14.5 vs. 13.9。相比之下，发现T3、3，3 '-T2和3'-T1的产生速率的以下显著降低：分别为19.1 vs. 38.8（P小于0.01）、13.2 vs. 36.8（P小于0.01）和15.7 vs. 28.6（P小于0.05）。假设甲状腺分泌对rT 3和3 '，5'-T2的贡献很小，计算了从T4到rT 3和进一步到3 '，5'-T2的转化率，发现肝硬化患者的转化率不受影响（对照组分别为48%和34%，对照组分别为34%和26%）。未观察到非脱碘代谢途径活性发生重大变化的趋势。总之，我们的数据表明，肝硬化深刻地改变了所有碘甲状腺原氨酸的动力学研究。此外，T4和rT 3的5-脱碘在肝硬化患者中不受影响。相反，在肝硬化患者中似乎存在对5 '-脱碘的普遍抑制。因此，我们的数据是兼容的存在一个共同的5-脱碘酶和一个共同的5 '-脱碘酶的顺序脱碘的碘甲腺原氨酸在人。
Turnover studies of T4, T3, rT3, 3',5'-diiodothyronine (3',5'-T2), 3,3'-diiodothyronine (3,3'-T2), and 3'-monoiodothyronine (3'-T1) were performed in 10 patients with alcoholic cirrhosis of the liver and 9 euthyroid, healthy controls using the single injection, noncompartmental approach. The kinetics of all 6 iodothyronines were studied in the same individuals. A newly developed, simple and reproducible gel separation technique, followed by antibody extraction, was used for the quantitation of tracer in serum. Serum T4, T3, and 3,3'-T2 levels were reduced in patients with liver cirrhosis, whereas serum rT3 and 3',5'-T2 levels were increased, Serum 3'-T1 levels were unaltered. A general tendency toward reduced MCRs was observed. The following median MCRs (liters per day per 70 kg BW) were found (cirrhotics vs. controls): T4, 1.13 vs. 1.19 (P = NS); T3, 16 vs. 20 (P less than 0.05); rT3, 81 vs. 147 (P less than 0.01); 3',5'-T2, 131 vs. 279 (P less than 0.01); 3,3'-T2, 533 vs. 1116 (P less than 0.01); and 3'-T1, 375 vs. 539 (P less than 0.05). The production rates (nanomoles per day per 70 kg BW) of T4, rT3, and 3,'5'-T2 were not significantly altered in patients with cirrhosis (cirrhotics vs. controls): 100 vs. 117, 47.5 vs. 52.0, and 14.5 vs. 13.9, respectively. In contrast, the following pronounced reductions in production rates of T3, 3,3'-T2, and 3'-T1 were found: 19.1 vs. 38.8 (P less than 0.01), 13.2 vs. 36.8 (P less than 0.01), and 15.7 vs. 28.6 (P less than 0.05), respectively. Assuming that thyroidal secretion contributes little rT3 and 3',5'-T2, the conversion rates from T4 to rT3 and further to 3',5'-T2 were calculated and found to be unaffected in patients with liver cirrhosis (48% vs. 34% in controls and 34% vs. 26% in controls, respectively). No tendency toward major changes in the activity of the nondeiodinative metabolic pathways was observed. In conclusion, our data show that liver cirrhosis profoundly changes the kinetics of all iodothyronines studied. Further, the 5-deiodination of T4 and rT3 is unaffected in patients with liver cirrhosis. In contrast, a general inhibition of the 5'-deiodinations seems to exist in patients with liver cirrhosis. Thus, our data are compatible with the existence of a common 5-deiodinase and a common 5'-deiodinase for the sequential deiodination of the iodothyronines in man.