Modular multidomain phosphoryl transfer proteins of bacteria
Modular multidomain phosphoryl transfer proteins of bacteria
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DOI：
10.1016/s0959-440x(97)80059-0
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发表时间：
1997-06-01
影响因子：
6.8
通讯作者：
Saier, MH
中科院分区：
文献类型：
--
作者：
Reizer, J;Saier, MH
最近对细菌多结构域磷酰转移蛋白的系统发育和结构分析表明，在进化过程中经常发生结构域间（而不是结构域内）的剪接和融合，以及结构域的复制和缺失。这些事件在某些其他蛋白质家族中非常罕见。结构域改组事件的例子说明了从磷酸烯醇化依赖性糖磷酸转移酶系统的超家族，其转录调节蛋白磷酸化的目标，传感器自激酶/响应调节信号转导系统，和ATP结合盒类型的permease。(C)当前生物有限公司
Recent phylogenetic and structural analyses of multidomain phosphoryl transfer proteins of bacteria have revealed that interdomain (but not intradomain) splicing and fusion, as well as domain duplication and deletion, have occurred frequently during evolution. These events have been found to be exceedingly rare in certain other protein families. Domain-shuffling events are illustrated by examples from the superfamilies of phosphoenolpyruvate-dependent sugar phosphotransferase systems, their transcriptional regulatory protein targets of phosphorylation, sensor autokinase/response regulator signal transduction systems, and permeases of the ATP-binding-cassette type. (C) Current Biology Ltd.