Reproductive performance in the next pregnancy for nulliparous women with history of first trimester spontaneous abortion
Reproductive performance in the next pregnancy for nulliparous women with history of first trimester spontaneous abortion
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DOI：
10.1007/s00404-013-2809-9
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发表时间：
2013-10-01
影响因子：
2.6
通讯作者：
Ibrahim, Zakia M.
中科院分区：
文献类型：
--
作者：
El Behery, Manal M.;Siam, Soha;Ibrahim, Zakia M.
为探讨首次自然流产后人工流产间隔时间对再次妊娠妇女生育能力的影响，对4,619例首次自然流产妇女进行了前瞻性队列研究。其中2,422例（52.4%）在流产后6个月内受孕（A组），2,197例（47.6%）在流产后12个月后受孕（B组）.主要结局为流产、活产、终止妊娠或下一次妊娠的异位妊娠。次要结局为早产、低出生体重儿、剖宫产率、先兆子痫发生率、第二次妊娠胎盘脱落和引产率，再次妊娠后6个月内再次妊娠者再次流产、终止妊娠或异位妊娠的可能性低于再次妊娠间隔12个月以上者。与首次自然流产后6个月内再次妊娠的妇女相比，流产间隔超过12个月的妇女在第二次妊娠中活产的可能性更小，更有可能进行剖腹产、早产或低出生体重儿。首次自然流产后6个月内妊娠的妇女有更好的生殖结局，随后妊娠的并发症发生率最低。
To determine whether interpregnancy interval after the first spontaneous abortion has an effect on reproductive performance of women in their next pregnancy.A prospective cohort study was conducted on 4,619 women with history of spontaneous abortion in their first pregnancy. Of them 2,422 (52.4 %) conceived within 6 months of the miscarriage (group A) and 2,197 47.6 % after 12 months (group B). The primary outcome was abortion, live birth, termination, or ectopic pregnancy in the next pregnancy. Secondary outcomes were preterm delivery, low birth weight infants, caesarean section rate and occurrence of preeclampsia, placental abruption and induced labour in the second pregnancy.Women who conceived again within 6 months were less likely to have another abortion, termination, or ectopic pregnancy compared with women with interpregnancy interval more than 12 months. Women with an interpregnancy interval more than 12 months were less likely to have live birth in the second pregnancy and more likely to have a caesarean section, preterm delivery, or infant of low birth weight compared with women who conceived again within 6 months.Women who conceive within 6 months after their first spontaneous abortion have better reproductive outcomes and the lowest complication rates in their subsequent pregnancy.