Structure and semisynthesis of platensimide A, produced by Streptomyces platensis
Structure and semisynthesis of platensimide A, produced by Streptomyces platensis
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DOI：
10.1021/ol800251v
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发表时间：
2008-05-01
期刊：
影响因子：
5.2
通讯作者：
Singh, Sheo B.
中科院分区：
文献类型：
--
作者：
Herath, Kithsiri B.;Zhang, Chaowei;Singh, Sheo B.
Platensimycin和Platencin是两种新型的天然产物抗生素，它们分别通过抑制脂肪酸生物合成途径中的FabF和FabF/FabH缩合酶来抑制细菌生长。对这些化合物的天然同源物的持续研究导致了platensic酸（游离的C-17四环烯酸）和platensimide A（2，4-二氨基丁酸酰胺衍生物）的分离。介绍了这些化合物的分离、结构、半合成和活性。
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.