Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia
Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia
复制标题
DOI：
10.1016/j.jneuroim.2015.02.012
复制
发表时间：
2015-04-15
影响因子：
3.3
通讯作者：
Dal-Pizzol, Felipe
中科院分区：
文献类型：
--
作者：
Comim, Clarissa M.;Silva, Napoleao C.;Dal-Pizzol, Felipe
本研究旨在评价脓毒症对氯胺酮诱导的精神分裂症动物模型行为学改变的影响。雄性Wistar大鼠进行盲肠结扎穿孔（CLP）与“基本支持”或假手术。30天后，通过注射氯胺酮使动物接受精神分裂症模型。在注射氯胺酮或生理盐水30分钟后进行行为测试。15和25 mg/kg剂量的氯胺酮增加了自发活动、社交互动中首次接触的潜伏期和刻板行为。脓毒症引起的一些变化可能与动物模型中发生精神分裂症的倾向有关。(C)2015 Elsevier B. V.版权所有。
This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25 mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model. (C) 2015 Elsevier B.V. All rights reserved.