Serotonin transporter genotype (5-HTTLPR):: Effects of neutral and undefined conditions on amygdala activation
Serotonin transporter genotype (5-HTTLPR):: Effects of neutral and undefined conditions on amygdala activation
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DOI：
10.1016/j.biopsych.2006.08.019
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发表时间：
2007-04-15
影响因子：
10.6
通讯作者：
Weinberger, Daniel R.
中科院分区：
文献类型：
--
作者：
Heinz, Andreas;Smolka, Michael N.;Weinberger, Daniel R.
背景资料：人类5-羟色胺转运体基因（SCL 6A 4）的多态性与5-羟色胺转运体的表达和杏仁核中对厌恶刺激的处理有关。功能成像研究表明，在呈现厌恶和中性线索时，短（s）等位基因的健康携带者比长（1）等位基因的携带者表现出更强的杏仁核激活。然而，最近的一份报告表明，这种相互作用是由杏仁核失活过程中提出的中性刺激在s carriers.Methods：功能磁共振成像评估杏仁核激活过程中提出的一个固定的交叉或情感厌恶或中性视觉刺激在29名健康男性。与情绪中性的条件相比，在未定义的状态下，如呈现固定交叉时，携带者的杏仁核激活增加。这一发现表明s携带者对相对不确定的刺激和环境表现出更强的杏仁核反应，我们认为这是压力。
Background: A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (1) carriers. However,a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers.Methods: Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men.Results: Amygdala activation was increased ins carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions.Conclusions: This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.