Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems.
Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems.
复制标题
神经接口系统的刺激/记录伪影传递函数估计的时间依赖性。
DOI：
10.1109/iembs.2009.5334297
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Gluckman,BruceJ
中科院分区：
文献类型：
--
作者：
Chernyy,Nick;Schiff,StevenJ;Gluckman,BruceJ
连续反馈使能控制系统需要同时测量系统状态和生成控制输出。在神经系统中，用于与神经活动相互作用的电刺激也在用于监测神经活动的测量点处产生额外的电位变化。这种刺激伪影通过添加共模和差分电位来混淆对潜在神经活动的记录。我们将此伪影建模为所施加电流的线性滤波版本。我们证明了一种方法来确定这个过滤器的性能，使用多锥度技术的长期植入动物刺激极化低频电场（PLEF）。当在连续记录的慢性实验中重复测量时，我们观察到高达50%的传递函数幅度的缓慢变化（图1）。这种变化反映了组织的体阻抗变化和电极界面特性变化的组合。这些变化需要跟踪和适应成功的慢性连续反馈神经控制系统。
A continuous feedback-enabled control system requires simultaneous measurements of the system states and generation of a control output. In neural systems, electric stimulation used to interact with neural activity also creates additional electrical potential variations at measurement points used to monitor neural activity. This stimulus artifact confounds recording of underlying neural activity through the addition of both common mode and differential potentials. We model this artifact as a linearly filtered version of the applied electrical current. We demonstrate a method to determine the properties of this filter using multi-taper techniques for chronically implanted animals stimulated with polarizing low-frequency electric fields (PLEF). When measured repeatedly in chronic experiments with continuous recordings, we observe slow changes of up to 50% transfer function magnitude (figure 1). Such changes reflect a combination bulk impedance changes of the tissue and changes in electrode interface properties. These variations need to be tracked and accommodated for successful chronic continuous feedback neural control systems.